SLC5A8

SLC5A8
Identifiers
Aliases	SLC5A8, AIT, SMCT, SMCT1, solute carrier family 5 member 8
External IDs	MGI: 2384916 HomoloGene: 64832 GeneCards: SLC5A8
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	101,210,407 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	88,929,515 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• transporter activity; • monocarboxylic acid transmembrane transporter activity; • passive transmembrane transporter activity; • symporter activity;
Cellular component	• integral component of membrane; • plasma membrane; • extracellular exosome; • apical plasma membrane; • membrane;
Biological process	• ion transport; • sodium ion transport; • apoptotic process; • transmembrane transport; • monocarboxylic acid transport; • NAD biosynthesis via nicotinamide riboside salvage pathway; • transport;
	Sources:Amigo / QuickGO
Orthologs
	160728
	216225
	ENSG00000262217; ENSG00000256870
	ENSMUSG00000020062
	Q8N695
	Q8BYF6
	NM_145913
	NM_145423
	NP_666018
	NP_663398
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium-coupled monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC5A8 gene.^[5]^[6]^[7]

References

1 2 3 ENSG00000256870 GRCh38: Ensembl release 89: ENSG00000262217, ENSG00000256870 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020062 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, Pourcher T (Jul 2002). "Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes". J Clin Endocrinol Metab. 87 (7): 3500–3. doi:10.1210/jc.87.7.3500. PMID 12107270.
↑ Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Kasturi L, Lutterbaugh J, Rerko RM, Casey G, Issa JP, Willis J, Willson JK, Plass C, Markowitz SD (Jul 2003). "SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers". Proc Natl Acad Sci U S A. 100 (14): 8412–7. doi:10.1073/pnas.1430846100. PMC 166243. PMID 12829793.
↑ "Entrez Gene: SLC5A8 solute carrier family 5 (iodide transporter), member 8".

Gupta N, Martin PM, Prasad PD, Ganapathy V (2006). "SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter". Life Sci. 78 (21): 2419–25. doi:10.1016/j.lfs.2005.10.028. PMID 16375929.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Miyauchi S, Gopal E, Fei YJ, Ganapathy V (2004). "Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids". J. Biol. Chem. 279 (14): 13293–6. doi:10.1074/jbc.C400059200. PMID 14966140.
Lacroix L, Pourcher T, Magnon C, et al. (2004). "Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters". J. Clin. Endocrinol. Metab. 89 (3): 1423–8. doi:10.1210/jc.2003-030542. PMID 15001644.
Hong C, Maunakea A, Jun P, et al. (2005). "Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8". Cancer Res. 65 (9): 3617–23. doi:10.1158/0008-5472.CAN-05-0048. PMID 15867356.
Paroder V, Spencer SR, Paroder M, et al. (2006). "Na+/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: Molecular characterization of SMCT". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7270–5. doi:10.1073/pnas.0602365103. PMC 1456061. PMID 16670197.
Hu S, Liu D, Tufano RP, et al. (2006). "Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer". Int. J. Cancer. 119 (10): 2322–9. doi:10.1002/ijc.22110. PMID 16858683.
Gopal E, Miyauchi S, Martin PM, et al. (2007). "Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract". Pharm. Res. 24 (3): 575–84. doi:10.1007/s11095-006-9176-1. PMID 17245649.
Coady MJ, Wallendorff B, Bourgeois F, et al. (2007). "Establishing a Definitive Stoichiometry for the Na+/Monocarboxylate Cotransporter SMCT1". Biophys. J. 93 (7): 2325–31. doi:10.1529/biophysj.107.108555. PMC 1965447. PMID 17526579.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000256870 GRCh38: Ensembl release 89: ENSG00000262217, ENSG00000256870 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020062 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid12107270-5] Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, Pourcher T (Jul 2002). "Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes". J Clin Endocrinol Metab. 87 (7): 3500–3. doi:10.1210/jc.87.7.3500. PMID 12107270.

[pmid12829793-6] Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Kasturi L, Lutterbaugh J, Rerko RM, Casey G, Issa JP, Willis J, Willson JK, Plass C, Markowitz SD (Jul 2003). "SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers". Proc Natl Acad Sci U S A. 100 (14): 8412–7. doi:10.1073/pnas.1430846100. PMC 166243. PMID 12829793.

[entrez-7] "Entrez Gene: SLC5A8 solute carrier family 5 (iodide transporter), member 8".

SLC5A8

See also

References

Further reading