Monocarboxylate transporter 10

SLC16A10
Identifiers
AliasesSLC16A10, MCT10, PRO0813, TAT1, solute carrier family 16 member 10
External IDsMGI: 1919722 HomoloGene: 75089 GeneCards: SLC16A10
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q21Start111,087,503 bp[1]
End111,231,194 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

117247

72472

Ensembl

ENSG00000112394

ENSMUSG00000019838

UniProt

Q8TF71

Q3U9N9

RefSeq (mRNA)

NM_018593

NM_001114332
NM_028247

RefSeq (protein)

NP_061063

NP_001107804
NP_082523

Location (UCSC)Chr 6: 111.09 – 111.23 MbChr 10: 40.03 – 40.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Monocarboxylate transporter 10 (MCT 10), also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene.[5][6][7] SLC16A10 is a member of the solute carrier family.

Function

SLC16A10 mediates Na+-independent transport of tryptophan, tyrosine, phenylalanine, and L-DOPA.[7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000112394 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019838 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: solute carrier family 16".
  6. ↑ Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H (May 2001). "Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters". J. Biol. Chem. 276 (20): 17221–8. doi:10.1074/jbc.M009462200. PMID 11278508.
  7. 1 2 Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H (January 2002). "The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location". Genomics. 79 (1): 95–103. doi:10.1006/geno.2001.6678. PMID 11827462.

Further reading

  • Toure A, Morin L, Pineau C, et al. (2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.
  • Friesema EC, Jansen J, Jachtenberg JW, et al. (2008). "Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10". Mol. Endocrinol. 22 (6): 1357–69. doi:10.1210/me.2007-0112. PMID 18337592.
  • Loubière LS, Vasilopoulou E, Bulmer JN, et al. (2010). "Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction". Placenta. 31 (4): 295–304. doi:10.1016/j.placenta.2010.01.013. PMID 20167367.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
  • Park SY, Kim JK, Kim IJ, et al. (2005). "Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule". Arch. Pharm. Res. 28 (4): 421–32. doi:10.1007/BF02977671. PMID 15918515.
  • Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169.


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