SLC34A2

SLC34A2
Identifiers
AliasesSLC34A2, NAPI-3B, NAPI-IIb, NPTIIb, solute carrier family 34 member 2
External IDsMGI: 1342284 HomoloGene: 2297 GeneCards: SLC34A2
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4p15.2Start25,648,011 bp[1]
End25,678,748 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10568

20531

Ensembl

ENSG00000157765

ENSMUSG00000029188

UniProt

O95436

Q9DBP0

RefSeq (mRNA)

NM_006424
NM_001177998
NM_001177999

NM_011402

RefSeq (protein)

NP_001171469
NP_001171470
NP_006415

NP_035532

Location (UCSC)Chr 4: 25.65 – 25.68 MbChr 5: 53.04 – 53.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.[5][6][7]

Clinical significance

Sodium-dependent phosphate transport protein 2b (NaPi2b) is a tumor-associated antigen.[8]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000157765 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029188 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Feild JA, Zhang L, Brun KA, Brooks DP, Edwards RM (Jun 1999). "Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine". Biochem Biophys Res Commun. 258 (3): 578–82. doi:10.1006/bbrc.1999.0666. PMID 10329428.
  6. ↑ Xu H, Bai L, Collins JF, Ghishan FK (Feb 2000). "Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)". Genomics. 62 (2): 281–4. doi:10.1006/geno.1999.6009. PMID 10610722.
  7. ↑ "Entrez Gene: SLC34A2 solute carrier family 34 (sodium phosphate), member 2".
  8. ↑ Yin BW, Kiyamova R, Chua R, Caballero OL, Gout I, Gryshkova V, Bhaskaran N, Souchelnytskyi S, Hellman U, Filonenko V, Jungbluth AA, Odunsi K, Lloyd KO, Old LJ, Ritter G. "Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas". Cancer Immun. 8: 3. PMC 2935786. PMID 18251464.

Further reading

  • Xu H, Collins JF, Bai L, et al. (2001). "Regulation of the human sodium-phosphate cotransporter NaP(i)-IIb gene promoter by epidermal growth factor". Am. J. Physiol., Cell Physiol. 280 (3): C628–36. PMID 11171583.
  • Segawa H, Kaneko I, Takahashi A, et al. (2002). "Growth-related renal type II Na/Pi cotransporter". J. Biol. Chem. 277 (22): 19665–72. doi:10.1074/jbc.M200943200. PMID 11880379.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Xu H, Uno JK, Inouye M, et al. (2005). "NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G175–81. doi:10.1152/ajpgi.00396.2004. PMID 15458926.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Corut A, Senyigit A, Ugur SA, et al. (2006). "Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis". Am. J. Hum. Genet. 79 (4): 650–6. doi:10.1086/508263. PMC 1592565. PMID 16960801.
  • Huqun, Izumi S, Miyazawa H, et al. (2007). "Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis". Am. J. Respir. Crit. Care Med. 175 (3): 263–8. doi:10.1164/rccm.200609-1274OC. PMID 17095743.


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