GDF1

GDF1
Identifiers
AliasesGDF1, DORV, DTGA3, RAI, growth differentiation factor 1, CHTD6
External IDsOMIM: 602880 MGI: 95683 HomoloGene: 105644 GeneCards: GDF1
Orthologs
SpeciesHumanMouse
Entrez

2657

14559

Ensembl

n/a

ENSMUSG00000109523

UniProt

P27539

P20863

RefSeq (mRNA)

NM_001492

NM_001163282
NM_008107

RefSeq (protein)

NP_001483

NP_001156754
NP_032133

Location (UCSC)n/aChr 8: 70.33 – 70.33 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Growth differentiation factor-1 (GDF1) is a protein that in humans is encoded by the GDF1 gene.[4]

GDF1 belongs to the transforming growth factor beta superfamily that has a role in left-right patterning and mesoderm induction during embryonic development.[5] It is found in the brain, spinal cord and peripheral nerves of embryos.[4][5]

References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000109523 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. 1 2 Lee SJ (May 1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4250–4. doi:10.1073/pnas.88.10.4250. PMC 51636. PMID 2034669.
  5. 1 2 Rankin CT, Bunton T, Lawler AM, Lee SJ (March 2000). "Regulation of left-right patterning in mice by growth/differentiation factor-1". Nat. Genet. 24 (3): 262–5. doi:10.1038/73472. PMID 10700179.

Further reading

  • Jiang JC, Kirchman PA, Zagulski M, et al. (1998). "Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human". Genome Res. 8 (12): 1259–72. doi:10.1101/gr.8.12.1259. PMID 9872981.
  • Lee SJ (1990). "Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily". Mol. Endocrinol. 4 (7): 1034–40. doi:10.1210/mend-4-7-1034. PMID 1704486.
  • Li J, Jia H, Xie L, et al. (2009). "Correlation of inhibitor of differentiation 1 expression to tumor progression, poor differentiation and aggressive behaviors in cervical carcinoma". Gynecol. Oncol. 114 (1): 89–93. doi:10.1016/j.ygyno.2009.03.016. PMID 19359031.
  • Ducy P, Karsenty G (2000). "The family of bone morphogenetic proteins". Kidney Int. 57 (6): 2207–14. doi:10.1046/j.1523-1755.2000.00081.x. PMID 10844590.
  • Lee SJ (1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4250–4. doi:10.1073/pnas.88.10.4250. PMC 51636. PMID 2034669.
  • Roessler E, Pei W, Ouspenskaia MV, et al. (2009). "Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly". Mol. Genet. Metab. 98 (1–2): 225–34. doi:10.1016/j.ymgme.2009.05.005. PMC 2774839. PMID 19553149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
  • Karkera JD, Lee JS, Roessler E, et al. (2007). "Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans". Am. J. Hum. Genet. 81 (5): 987–94. doi:10.1086/522890. PMC 2265655. PMID 17924340.
  • Polymeropoulos MH, Xiao H, Sikela JM, et al. (1993). "Chromosomal distribution of 320 genes from a brain cDNA library". Nat. Genet. 4 (4): 381–6. doi:10.1038/ng0893-381. PMID 8401586.


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