Bone morphogenetic protein 8B

BMP8B
Identifiers
Aliases	BMP8B, BMP8, OP2, bone morphogenetic protein 8b
External IDs	OMIM: 602284 HomoloGene: 74865 GeneCards: BMP8B
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	39,788,861 bp[1]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transforming growth factor beta receptor binding; • cytokine activity; • BMP receptor binding; • growth factor activity;
Cellular component	• extracellular region; • extracellular space;
Biological process	• regulation of apoptotic process; • multicellular organism development; • skeletal system development; • positive regulation of pathway-restricted SMAD protein phosphorylation; • cartilage development; • cell differentiation; • regulation of MAPK cascade; • SMAD protein signal transduction; • cell development; • BMP signaling pathway; • ossification; • regulation of receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	656
	n/a
	ENSG00000116985
	n/a
	P34820
	n/a
	NM_001720
	n/a
	NP_001711
	n/a
	Wikidata
View/Edit Human

Bone morphogenetic protein 8B is a protein that in humans is encoded by the BMP8B gene.^[3]^[4]^[5]

The protein encoded by this gene is a member of the TGF-β superfamily. It has close sequence homology to BMP7 and BMP5 and is believed to play a role in bone and cartilage development. It has been shown to be expressed in the hippocampus of murine embryos.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116985 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ Ozkaynak E, Schnegelsberg PN, Jin DF, Clifford GM, Warren FD, Drier EA, Oppermann H (Jan 1993). "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis". J Biol Chem. 267 (35): 25220–7. PMID 1460021.
↑ DiLeone RJ, King JA, Storm EE, Copeland NG, Jenkins NA, Kingsley DM (Jun 1997). "The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4". Genomics. 40 (1): 196–8. doi:10.1006/geno.1996.4533. PMID 9070944.
1 2 "Entrez Gene: BMP8B bone morphogenetic protein 8b (osteogenic protein 2)".

External links

Human BMP8B genome location and BMP8B gene details page in the UCSC Genome Browser.

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Wen XZ, Akiyama Y, Baylin SB, Yuasa Y (2006). "Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas". Oncogene. 25 (18): 2666–73. doi:10.1038/sj.onc.1209297. PMID 16314833.
Saito T, Ji G, Shinzawa H, et al. (2004). "Genetic variations in humans associated with differences in the course of hepatitis C". Biochem. Biophys. Res. Commun. 317 (2): 335–41. doi:10.1016/j.bbrc.2004.03.056. PMID 15063762.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ying Y, Qi X, Zhao GQ (2001). "Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways". Proc. Natl. Acad. Sci. U.S.A. 98 (14): 7858–62. doi:10.1073/pnas.151242798. PMC 35432. PMID 11427739.
Ying Y, Liu XM, Marble A, et al. (2000). "Requirement of Bmp8b for the generation of primordial germ cells in the mouse". Mol. Endocrinol. 14 (7): 1053–63. doi:10.1210/mend.14.7.0479. PMID 10894154.
Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116985 - Ensembl, May 2017

[2] "Human PubMed Reference:".

[pmid1460021-3] Ozkaynak E, Schnegelsberg PN, Jin DF, Clifford GM, Warren FD, Drier EA, Oppermann H (Jan 1993). "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis". J Biol Chem. 267 (35): 25220–7. PMID 1460021.

[pmid9070944-4] DiLeone RJ, King JA, Storm EE, Copeland NG, Jenkins NA, Kingsley DM (Jun 1997). "The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4". Genomics. 40 (1): 196–8. doi:10.1006/geno.1996.4533. PMID 9070944.

[entrez-5] 1 2 "Entrez Gene: BMP8B bone morphogenetic protein 8b (osteogenic protein 2)".

Bone morphogenetic protein 8B

References

External links

Further reading