Zinc finger FYVE domain-containing protein 9

ZFYVE9
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1DEV, 1MK2, 4BKW
Identifiers
Aliases	ZFYVE9, MADHIP, NSP, PPP1R173, SARA, SMADIP, zinc finger FYVE-type containing 9
External IDs	MGI: 2652838 HomoloGene: 3527 GeneCards: ZFYVE9
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	52,346,686 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	108,780,798 bp[2]
Gene ontology
Molecular function	• 1-phosphatidylinositol binding; • serine-type peptidase activity; • protein binding; • metal ion binding; • protein domain specific binding;
Cellular component	• cytoplasm; • endosome; • early endosome; • early endosome membrane; • membrane; • cytosol; • intracellular membrane-bounded organelle; • macromolecular complex;
Biological process	• endocytosis; • transforming growth factor beta receptor signaling pathway; • proteolysis; • endosomal transport;
	Sources:Amigo / QuickGO
Orthologs
	9372
	230597
	ENSG00000157077
	ENSMUSG00000034557
	O95405
	n/a
	NM_004799; NM_007323; NM_007324
	NM_183300; NM_001347163
	NP_004790; NP_015563
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene.^[5] SARA contains a double zinc finger (FYVE domain).

SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.^[6] It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates form SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000157077 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034557 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL (December 1998). "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor". Cell. 95 (6): 779–791. doi:10.1016/S0092-8674(00)81701-8. PMID 9865696.
↑ Lin HK, Bergmann S, Pandolfi PP (September 2004). "Cytoplasmic PML function in TGF-beta signalling". Nature. 431 (7005): 205–211. doi:10.1038/nature02783. PMID 15356634.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000157077 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034557 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid9865696-5] Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL (December 1998). "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor". Cell. 95 (6): 779–791. doi:10.1016/S0092-8674(00)81701-8. PMID 9865696.

[pmid15356634-6] Lin HK, Bergmann S, Pandolfi PP (September 2004). "Cytoplasmic PML function in TGF-beta signalling". Nature. 431 (7005): 205–211. doi:10.1038/nature02783. PMID 15356634.