Bone morphogenetic protein 10

BMP10
Identifiers
AliasesBMP10, entrez:27302, bone morphogenetic protein 10
External IDsOMIM: 608748 MGI: 1338820 HomoloGene: 7644 GeneCards: BMP10
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p13.3Start68,865,481 bp[1]
End68,871,517 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

27302

12154

Ensembl

ENSG00000163217

ENSMUSG00000030046

UniProt

O95393

Q9R229

RefSeq (mRNA)

NM_014482

NM_009756

RefSeq (protein)

NP_055297

NP_033886

Location (UCSC)Chr 2: 68.87 – 68.87 MbChr 6: 87.43 – 87.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene.[5][6]

BMP10 is a polypeptide belonging to the TGF-β superfamily of proteins.[6] It is a novel protein that, unlike most other BMP's, is likely to be involved in the trabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-β superfamily.

Further reading

  • Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
  • Mazerbourg S, Sangkuhl K, Luo CW, et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem. 280 (37): 32122–32. doi:10.1074/jbc.M504629200. PMID 16049014.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nakano N, Hori H, Abe M, et al. (2007). "Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy". Am. J. Physiol. Heart Circ. Physiol. 293 (6): H3396–403. doi:10.1152/ajpheart.00311.2007. PMID 17921333.
  • Marroni F, Pfeufer A, Aulchenko YS, et al. (2009). "A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project". Circ Cardiovasc Genet. 2 (4): 322–8. doi:10.1161/CIRCGENETICS.108.833806. PMC 2760953. PMID 20031603.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • David L, Mallet C, Mazerbourg S, et al. (2007). "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells". Blood. 109 (5): 1953–61. doi:10.1182/blood-2006-07-034124. PMID 17068149.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163217 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030046 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: bone morphogenetic protein 10".
  6. 1 2 Neuhaus H, Rosen V, Thies RS (February 1999). "Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily". Mech. Dev. 80 (2): 181–4. doi:10.1016/S0925-4773(98)00221-4. PMID 10072785.


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