Bone morphogenetic protein 8A

BMP8A
Identifiers
Aliases	BMP8A, entrez:353500, bone morphogenetic protein 8a
External IDs	MGI: 104515 HomoloGene: 135983 GeneCards: BMP8A
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	39,525,935 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	123,343,252 bp[2]
Gene ontology
Molecular function	• transforming growth factor beta receptor binding; • cytokine activity; • BMP receptor binding; • growth factor activity;
Cellular component	• extracellular region; • extracellular space;
Biological process	• regulation of apoptotic process; • multicellular organism development; • positive regulation of pathway-restricted SMAD protein phosphorylation; • cartilage development; • negative regulation of insulin secretion; • cell differentiation; • regulation of MAPK cascade; • SMAD protein signal transduction; • cell development; • BMP signaling pathway; • ossification; • diet induced thermogenesis; • regulation of receptor activity; • energy homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	353500
	12163
	ENSG00000183682
	ENSMUSG00000032726
	Q7Z5Y6
	P34821
	NM_181809
	NM_001256019; NM_007558
	NP_861525
	NP_001242948; NP_031584
	Wikidata
View/Edit Human	View/Edit Mouse

Bone morphogenetic protein 8A (BMP8A) is a protein that in humans is encoded by the BMP8A gene.^[5]

BMP8A is a polypeptide member of the TGFβ superfamily of proteins. It, like other bone morphogenetic proteins (BMPs), is involved in the development of bone and cartilage. BMP8A may be involved in epithelial osteogenesis. It also plays a role in bone homeostasis. It is a disulfide-linked homodimer.

References

Human BMP8A genome location and BMP8A gene details page in the UCSC Genome Browser.

Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

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