Bone morphogenetic protein 3

BMP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBMP3, BMP-3A, bone morphogenetic protein 3
External IDsOMIM: 112263 MGI: 88179 HomoloGene: 927 GeneCards: BMP3
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q21.21Start81,030,965 bp[1]
End81,057,531 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

651

110075

Ensembl

ENSG00000152785

ENSMUSG00000029335

UniProt

P12645

Q8BHE5

RefSeq (mRNA)

NM_001201

NM_173404
NM_001310677

RefSeq (protein)

NP_001192

NP_001297606
NP_775580

Location (UCSC)Chr 4: 81.03 – 81.06 MbChr 5: 98.85 – 98.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene.[5]

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured tissues.

Cancer

BMP3 is hypermethylated in many cases of colorectal cancer (CRC) and hence along with other hypermethylated genes, may be used as an biomarker to detect early stage CRC.[6][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000152785 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029335 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)".
  6. ↑ Rasmussen SL, Krarup HB, Sunesen KG, Pedersen IS, Madsen PH, Thorlacius-Ussing O (June 2016). "Hypermethylated DNA as a biomarker for colorectal cancer: a systematic review". Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland. 18 (6): 549–61. doi:10.1111/codi.13336. PMID 26998585.
  7. ↑ Kormi SM, Ardehkhani S, Kerachian MA (November 2017). "New insights into colorectal cancer screening and early detection tests". Colorectal Cancer. 6 (2): 63–68. doi:10.2217/crc-2017-0007.

Further reading

  • Dickinson ME, Kobrin MS, Silan CM, Kingsley DM, Justice MJ, Miller DA, Ceci JD, Lock LF, Lee A, Buchberg AM (March 1990). "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci". Genomics. 6 (3): 505–20. doi:10.1016/0888-7543(90)90480-I. PMID 1970330.
  • Tabas JA, Zasloff M, Wasmuth JJ, Emanuel BS, Altherr MR, McPherson JD, Wozney JM, Kaplan FS (February 1991). "Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3". Genomics. 9 (2): 283–9. doi:10.1016/0888-7543(91)90254-C. PMID 2004778.
  • Paralkar VM, Nandedkar AK, Pointer RH, Kleinman HK, Reddi AH (October 1990). "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen". The Journal of Biological Chemistry. 265 (28): 17281–4. PMID 2211625.
  • Rosen V, Wozney JM, Wang EA, Cordes P, Celeste A, McQuaid D, Kurtzberg L (1990). "Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone". Connective Tissue Research. 20 (1–4): 313–9. doi:10.3109/03008208909023902. PMID 2612162.
  • Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA (December 1988). "Novel regulators of bone formation: molecular clones and activities". Science. 242 (4885): 1528–34. doi:10.1126/science.3201241. PMID 3201241.
  • Faucheux C, Ulysse F, Bareille R, Reddi AH, Amédée J (December 1997). "Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation". Biochemical and Biophysical Research Communications. 241 (3): 787–93. doi:10.1006/bbrc.1997.7792. PMID 9434787.
  • Daluiski A, Engstrand T, Bahamonde ME, Gamer LW, Agius E, Stevenson SL, Cox K, Rosen V, Lyons KM (January 2001). "Bone morphogenetic protein-3 is a negative regulator of bone density". Nature Genetics. 27 (1): 84–8. doi:10.1038/83810. PMID 11138004.
  • Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL (October 2001). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histology and Histopathology. 16 (4): 1013–9. PMID 11642720.
  • Kloen P, Di Paola M, Borens O, Richmond J, Perino G, Helfet DL, Goumans MJ (September 2003). "BMP signaling components are expressed in human fracture callus". Bone. 33 (3): 362–71. doi:10.1016/S8756-3282(03)00191-1. PMID 13678778.
  • Kang Q, Sun MH, Cheng H, Peng Y, Montag AG, Deyrup AT, Jiang W, Luu HH, Luo J, Szatkowski JP, Vanichakarn P, Park JY, Li Y, Haydon RC, He TC (September 2004). "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery". Gene Therapy. 11 (17): 1312–20. doi:10.1038/sj.gt.3302298. PMID 15269709.
  • Chen AL, Fang C, Liu C, Leslie MP, Chang E, Di Cesare PE (November 2004). "Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage". Journal of Orthopaedic Research. 22 (6): 1188–92. doi:10.1016/j.orthres.2004.02.013. PMID 15475196.
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