Flugestone acetate
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Clinical data | |
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Trade names | Cronolone, others |
Synonyms | Flurogestone acetate; Fluorogestone acetate; FGA; NSC-65411; SC-9880; 17α-Acetoxy-9α-fluoro-11β-hydroxyprogesterone |
Routes of administration | Intravaginal |
Drug class | Progestin; Progestogen; Progestogen ester |
Identifiers | |
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CAS Number | |
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ChemSpider | |
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KEGG | |
ChEMBL | |
Chemical and physical data | |
Formula | C23H31FO5 |
Molar mass | 406.488 g/mol |
3D model (JSmol) | |
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Flugestone acetate (abbreviated as FGA), sold under the brand name Cronolone among others, is a progestin medication which is used in veterinary medicine.[1][2][3][4][5][6]
Uses
Veterinary
FGA is used as an intravaginal sponge preparation to synchronize estrus in ewes and goats.[2][4][5][6]
Chemistry
FGA, also known as 17α-acetoxy-9α-fluoro-11β-hydroxyprogesterone or as 17α-acetoxy-9α-fluoro-11β-hydroxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone.[1][3] It is the C17α acetate ester of flugestone.[1][3][2]
History
FGA was developed and marketed by G.D. Searle & Company in the 1960s.[7][8]
Society and culture
Generic names
Flugestone acetate is the generic name of the drug and its INN and BANM, while flurogestone acetate is its USAN.[1][3][2][9] Flugestone is the BAN and DCIT of the unesterified free alcohol form.[1][3][2][9] FGA is also known by its developmental code names NSC-65411 and SC-9880.[1][3][2][9]
Brand names
FGA is or has been marketed under the brand names Chronogest, Chrono-Gest, Crono-Gest, Cronolone, Gyncro-Mate, Ova-Gest, Ovakron, Synchro-Mate, Syncro Part, and Syncropart.[1][3][2][9]
Availability
FGA is marketed for veterinary use in Australia, France, Ireland, Israel, Italy, the Netherlands, South Africa, and the United Kingdom.[3][9]
References
- 1 2 3 4 5 6 7 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 559. ISBN 978-1-4757-2085-3.
- 1 2 3 4 5 6 7 Dr. Ian Morton; I.K. Morton; Judith M. Hall (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 122–. ISBN 978-0-7514-0499-9.
- 1 2 3 4 5 6 7 8 Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 451–. ISBN 978-3-88763-075-1.
- 1 2 Office of the Federal Register (U S ); U. s. Government Printing Office (29 May 2012). Code of Federal Regulations Title 21: Food and Drug Administration: Parts 500-599, Revised April 1, 2012. Government Printing Office. pp. 359–. ISBN 978-0-16-090718-0.
- 1 2 Robert S. Youngquist; Walter R. Threlfall (23 November 2006). Current Therapy in Large Animal Theriogenology. Elsevier Health Sciences. pp. 2640–. ISBN 1-4377-1340-8.
- 1 2 Virginia P. Studdert; Clive C. Gay; Douglas C. Blood (9 December 2011). Saunders Comprehensive Veterinary Dictionary. Elsevier Health Sciences. pp. 2673–. ISBN 0-7020-4744-9.
- ↑ Animal Husbandry Research: Reports on Agricultural Industry. 1967. p. 60.
- ↑ Dairy Science Handbook. Agriservices Foundation. 1971. p. 10.
- 1 2 3 4 5 https://www.drugs.com/international/flugestone.html