Flumetasone

Flumetasone

Clinical data
Synonyms	Flumethasone (USAN)
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Topical
ATC code	D07AB03 (WHO) , D07XB01 (WHO) (combinations), QH02AB90 (WHO)
Pharmacokinetic data
Metabolism	Hepatic, CYP3A4-mediated
Identifiers
IUPAC name (1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
CAS Number	2135-17-3 Y
PubChem CID	16490
ChemSpider	15632 N
UNII	LR3CD8SX89
KEGG	D04208 Y
ChEBI	CHEBI:34764 N
ChEMBL	CHEMBL1201392 N
ECHA InfoCard	100.016.701
Chemical and physical data
Formula	C22H28F2O5
Molar mass	410.452 g/mol
3D model (JSmol)	Interactive image
SMILES C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C)F
InChI InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 N Key:WXURHACBFYSXBI-GQKYHHCASA-N N
NY (what is this?)  (verify)

Flumetasone (INN), also known as flumethasone (USAN),^[1] is a corticosteroid for topical use. Trade names include Locacorten, Locorten, and Orsalin. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis. It is usually formulated as the pivalic acid ester prodrug flumetasone pivalate.

Flumethasone is 420 times as potent as cortisone in an animal model for anti-inflammatory activity.

See also

• Glucocorticoid
• Corticosteroid
• Triamcinolone acetonide

References