Enterobacteriaceae

Enterobacteriaceae
Citrobacter freundii, one member of the family
Scientific classification
Domain:Bacteria
Phylum:Proteobacteria
Class:Gammaproteobacteria
Order:Enterobacteriales
Family:Enterobacteriaceae
Rahn, 1937
Genera[1]

See text

The Enterobacteriaceae are a large family of Gram-negative bacteria. This family is the only representative in the order Enterobacteriales of the class Gammaproteobacteria in the phylum Proteobacteria.[2][3][4][5]

Enterobacteriaceae includes, along with many harmless symbionts, many of the more familiar pathogens, such as Salmonella, Escherichia coli, Yersinia pestis, Klebsiella, and Shigella. Other disease-causing bacteria in this family include Proteus, Enterobacter, Serratia, and Citrobacter. Phylogenetically, in the Enterobacteriales, several peptidoglycan-less insect endosymbionts form a sister clade to the Enterobacteriaceae, but as they are not validly described, this group is not officially a taxon; examples of these species are Sodalis, Buchnera, Wigglesworthia, Baumannia cicadellinicola, and Blochmannia, but not former Rickettsias.[6] Members of the Enterobacteriaceae can be trivially referred to as enterobacteria or "enteric bacteria",[7] as several members live in the intestines of animals. In fact, the etymology of the family is enterobacterium with the suffix to designate a family (aceae)—not after the genus Enterobacter (which would be "Enterobacteraceae")—and the type genus is Escherichia.

Characteristics

Members of the Enterobacteriaceae are bacilli (rod-shaped), and are typically 1–5 μm in length. They typically appear as medium to large-sized grey colonies on blood agar, although some can express pigments (such as Serratia marcescens). Like other proteobacteria, enterobactericeae have Gram-negative stains,[8] and they are facultative anaerobes, fermenting sugars to produce lactic acid and various other end products. Most also reduce nitrate to nitrite, although exceptions exist (e.g. Photorhabdus). Unlike most similar bacteria, enterobacteriaceae generally lack cytochrome C oxidase, although there are exceptions (e.g. Plesiomonas shigelloides). Most have many flagella used to move about, but a few genera are nonmotile. They are not spore-forming. Catalase reactions vary among Enterobacteriaceae.

Many members of this family are normal members of the gut microbiota in humans and other animals, while others are found in water or soil, or are parasites on a variety of different animals and plants. Escherichia coli is one of the most important model organisms, and its genetics and biochemistry have been closely studied.

Most members of Enterobacteriaceae have peritrichous, type I fimbriae involved in the adhesion of the bacterial cells to their hosts. Some enterobacteria produce endotoxins. Endotoxins reside in the cell wall and are released when the cell dies and the cell wall disintegrates. Some members of the Enterobacteriaceae produce endotoxins that, when released into the bloodstream following cell lysis, cause a systemic inflammatory and vasodilatory response. The most severe form of this is known as endotoxic shock, which can be rapidly fatal.

Genera

Accepted

Candidatus

  • "Candidatus Annandia"
  • "Candidatus Aschnera"
  • "Candidatus Benitsuchiphilus"
  • "Candidatus Curculioniphilus"
  • "Candidatus Cuticobacterium"
  • "Candidatus Gillettellia"
  • "Candidatus Hamiltonella"
  • "Candidatus Hartigia"
  • "Candidatus Ishikawaella"
  • "Candidatus Kleidoceria"
  • "Candidatus Macropleicola"
  • "Candidatus Moranella"
  • "Candidatus Phlomobacter"
  • "Candidatus Profftia"
  • "Candidatus Purcelliella"
  • "Candidatus Regiella"
  • "Candidatus Riesia"
  • "Candidatus Rohrkolberia"
  • "Candidatus Rosenkranzia"
  • "Candidatus Schneideria"
  • "Candidatus Stammerula"
  • "Candidatus Tachikawaea"

Provisional

  • Aquamonas
  • Aranicola
  • Atlantibacter
  • Chania
  • Grimontella
  • Guhaiyinggella
  • Margalefia
  • Tiedjeia

Identification

To identify different genera of Enterobacteriaceae, a microbiologist may run a series of tests in the lab. These include:[9]

In a clinical setting, three species make up 80 to 95% of all isolates identified. These are Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis.

Antibiotic resistance

Several Enterobacteriaceae strains have been isolated which are resistant to antibiotics including carbapenems, which are often claimed as "the last line of antibiotic defense" against resistant organisms. For instance, some Klebsiella pneumoniae strains are carbapenem resistant.[10]

References

  1. ↑ "List of genera included in families - Enterobacteriaceae". List of Prokaryotic Names with Standing in Nomenclature. Retrieved 26 June 2016.
  2. ↑ Don J. Brenner; Noel R. Krieg; James T. Staley (July 26, 2005) [1984 (Williams & Wilkins)]. George M. Garrity, ed. The Gammaproteobacteria. Bergey's Manual of Systematic Bacteriology. 2B (2nd ed.). New York: Springer. p. 1108. ISBN 978-0-387-24144-9. British Library no. GBA561951.
  3. ↑ Zipcodezoo site Enterobacteriales Archived 2014-04-27 at the Wayback Machine. accessed 9 Mar 2013
  4. ↑ NCBI Enterobacteriales accessed 9 Mar 2013
  5. ↑ Taxonomicon Enterobacteriales accessed 9 Mar 2013
  6. ↑ Williams, K. P.; Gillespie, J. J.; Sobral, B. W. S.; Nordberg, E. K.; Snyder, E. E.; Shallom, J. M.; Dickerman, A. W. (2010). "Phylogeny of Gammaproteobacteria". Journal of Bacteriology. 192 (9): 2305–2314. doi:10.1128/JB.01480-09. PMC 2863478. PMID 20207755.
  7. ↑ http://inst.bact.wisc.edu/inst/index.php?module=book&type=user&func=displayarticle&art_id=268
  8. ↑ "Dorlands Medical Dictionary:Enterobacteriaceae".
  9. ↑ MacFaddin, Jean F. Biochemical Tests for Identification of Medical Bacteria. Williams & Wilkins, 1980, p 441.
  10. ↑ Centers for Disease Control and Prevention - Klebsiella Quotation: "Increasingly, Klebsiella bacteria have developed antimicrobial resistance, most recently to the class of antibiotics known as carbapenems."
  • Enterobacteriaceae genomes and related information at PATRIC, a Bioinformatics Resource Center funded by NIAID
  • Evaluation of new computer-enhanced identification program for microorganisms: adaptation of BioBASE for identification of members of the family Enterobacteriaceae
  • Brown, A.E. (2009). Benson's microbiological applications: laboratory manual in general microbiology. New York: McGraw- Hill.
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