Kyotorphin
Kyotorphin (L-tyrosyl-L-arginine) is a neuroactive dipeptide which plays a role in pain regulation in the brain. It was first isolated from bovine brain, by Japanese scientists in 1979.[1] Kyotorphin was named for the site of its discovery, Kyoto, Japan and because of its morphine- (or endorphin-) like analgesic activity. Kyotorphin has an analgesic effect, but it does not interact with the opioid receptors. Instead, it acts by releasing met-enkephalin and stabilizing it from degradation. It may also possess properties of neuromediator/neuromodulator. It has been shown that kyotorphin is present in the human cerebrospinal fluid and that its concentration is lower in patients with persistent pain.[2]
 | |
| Names | |
|---|---|
| IUPAC name
(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-5- (diaminomethylideneamino)pentanoic acid | |
| Other names
Kiotorphin L-Tyrosyl-L-arginine | |
| Identifiers | |
3D model (JSmol) |
|
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
PubChem CID |
|
| UNII | |
CompTox Dashboard (EPA) |
|
| |
| |
| Properties | |
| C15H23N5O4 | |
| Molar mass | 337.380 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
  | |
| Infobox references | |
References
- Takagi H, Shiomi H, Ueda H, Amano H (November 1979). "A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser". Nature. 282 (5737): 410–2. doi:10.1038/282410a0. PMID 228202.
- Nishimura K, Kaya K, Hazato T, Ueda H, Satoh M, Takagi H (November 1991). "[Kyotorphin like substance in human cerebrospinal fluid of patients with persistent pain]". Masui (in Japanese). 40 (11): 1686–90. PMID 1766121.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.