IFNB1

IFNB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AU1
Identifiers
Aliases	IFNB1, IFB, IFF, IFNB, IFN-beta, interferon beta 1
External IDs	OMIM: 147640 MGI: 107657 HomoloGene: 1640 GeneCards: IFNB1
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	21,077,942 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	88,522,774 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• cytokine activity; • cytokine receptor binding; • chloramphenicol O-acetyltransferase activity; • type I interferon receptor binding;
Cellular component	• extracellular; • extracellular region;
Biological process	• positive regulation of peptidyl-serine phosphorylation of STAT protein; • blood coagulation; • B cell differentiation; • cellular response to interferon-beta; • regulation of MHC class I biosynthetic process; • negative regulation of viral genome replication; • natural killer cell activation; • B cell activation involved in immune response; • positive regulation of apoptotic signaling pathway; • cell surface receptor signaling pathway; • natural killer cell activation involved in immune response; • response to exogenous dsRNA; • response to virus; • T cell activation involved in immune response; • positive regulation of transcription from RNA polymerase II promoter; • defense response; • negative regulation of T cell differentiation; • positive regulation of innate immune response; • cellular response to exogenous dsRNA; • negative regulation of T-helper 2 cell cytokine production; • defense response to virus; • type I interferon signaling pathway; • regulation of receptor activity; • humoral immune response; • B cell proliferation; • adaptive immune response; • cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3456
	15977
	ENSG00000171855
	ENSMUSG00000048806
	P01574
	P01575
	NM_002176
	NM_010510
	NP_002167
	NP_034640
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon beta is a protein that in humans is encoded by the IFNB1 gene.[5] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.

Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.

References

GRCh38: Ensembl release 89: ENSG00000171855 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000048806 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: IFNB1 interferon, beta 1, fibroblast".

Biron CA, Nguyen KB, Pien GC (2002). "Innate immune responses to LCMV infections: natural killer cells and cytokines". Curr. Top. Microbiol. Immunol. Current Topics in Microbiology and Immunology. 263: 7–27. doi:10.1007/978-3-642-56055-2_2. ISBN 978-3-642-62724-8. PMID 11987821.
Conti L, Fantuzzi L, Del Cornò M, et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis". Immunobiology. 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID 15481145.
Bekisz J, Schmeisser H, Hernandez J, et al. (2005). "Human interferons alpha, beta and omega". Growth Factors. 22 (4): 243–51. doi:10.1080/08977190400000833. PMID 15621727.
Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines". Mini Reviews in Medicinal Chemistry. 5 (12): 1093–101. doi:10.2174/138955705774933383. PMID 16375755.
Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
Flores I, Mariano TM, Pestka S (1991). "Human interferon omega (omega) binds to the alpha/beta receptor". J. Biol. Chem. 266 (30): 19875–7. PMID 1834641.
May LT, Sehgal PB (1985). "On the relationship between human interferon alpha 1 and beta 1 genes". J. Interferon Res. 5 (3): 521–6. doi:10.1089/jir.1985.5.521. PMID 2414376.
Francois DT, Katona IM, June CH, et al. (1988). "Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens". Clin. Immunol. Immunopathol. 48 (3): 297–306. doi:10.1016/0090-1229(88)90023-2. PMID 3135963.
Conradt HS, Egge H, Peter-Katalinic J, et al. (1987). "Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line". J. Biol. Chem. 262 (30): 14600–5. PMID 3667593.
Blank KJ, McKernan LN, Murasko DM (1985). "Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation". J. Interferon Res. 5 (1): 215–21. doi:10.1089/jir.1985.5.215. PMID 3872918.
Derynck R, Content J, DeClercq E, et al. (1980). "Isolation and structure of a human fibroblast interferon gene". Nature. 285 (5766): 542–7. doi:10.1038/285542a0. PMID 6157094.
Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M (1980). "The nucleotide sequence of human fibroblast interferon cDNA". Gene. 10 (1): 11–5. doi:10.1016/0378-1119(80)90138-9. PMID 6157601.
Houghton M, Easton MA, Stewart AG, et al. (1981). "The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase". Nucleic Acids Res. 8 (13): 2885–94. doi:10.1093/nar/8.13.2885. PMC 324132. PMID 6159580.
Goeddel DV, Shepard HM, Yelverton E, et al. (1981). "Synthesis of human fibroblast interferon by E. coli". Nucleic Acids Res. 8 (18): 4057–74. doi:10.1093/nar/8.18.4057. PMC 324219. PMID 6159584.
Houghton M, Stewart AG, Doel SM, et al. (1981). "The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers". Nucleic Acids Res. 8 (9): 1913–31. doi:10.1093/nar/8.9.1913. PMC 324047. PMID 6159597.
Wetzel R (1981). "Assignment of the disulphide bonds of leukocyte interferon". Nature. 289 (5798): 606–7. doi:10.1038/289606a0. PMID 6162107.
Lawn RM, Adelman J, Franke AE, et al. (1981). "Human fibroblast interferon gene lacks introns". Nucleic Acids Res. 9 (5): 1045–52. doi:10.1093/nar/9.5.1045. PMC 326735. PMID 6164984.
Shepard HM, Leung D, Stebbing N, Goeddel DV (1982). "A single amino acid change in IFN-beta1 abolishes its antiviral activity". Nature. 294 (5841): 563–5. doi:10.1038/294563a0. PMID 6171735.
Content J, De Wit L, Pierard D, et al. (1982). "Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta". Proc. Natl. Acad. Sci. U.S.A. 79 (9): 2768–72. doi:10.1073/pnas.79.9.2768. PMC 346287. PMID 6178110.
Fiers W, Remaut E, Devos R, et al. (1983). "The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells". Philos. Trans. R. Soc. Lond. B Biol. Sci. 299 (1094): 29–38. doi:10.1098/rstb.1982.0103. PMID 6183692.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171855 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048806 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IFNB1 interferon, beta 1, fibroblast".

IFNB1

References

Further reading