Suprofen

Suprofen
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy
category
  • US: C (Risk not ruled out)
    Routes of
    administration    		 Oral, eye drops
    ATC code
    Legal status
    Legal status
    • Discontinued
    Pharmacokinetic data
    Protein binding 20%
    Identifiers
    CAS Number
    PubChem CID
    IUPHAR/BPS
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEBI
    ChEMBL
    ECHA InfoCard 100.050.071 Edit this at Wikidata
    Chemical and physical data
    Formula C14H12O3S
    Molar mass 260.309 g/mol
    3D model (JSmol)
     ☒N☑Y (what is this?)  (verify)

    Suprofen is a nonsteroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica[1] that was marketed as 1% eye drops under the trade name Profenal.

    Uses

    Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.[3] This application has been discontinued as well, at least in the US.[4]

    References

    1. ↑ Janssen, Paul A.; Van Daele, Georges H. P.; Boey, Jozef M. "Antiphlogistic aroyl-substituted phenylacetic acid derivatives" (1974) DE 2353357
    2. ↑ Nies A S (1988). "Renal effects of nonsteroidal anti-inflammatory drugs". Agents and actions. 24: 95–106. doi:10.1007/978-3-0348-9160-8_9. PMID 3142236.
    3. ↑ Guidance for FDA Staff and Industry Compliance Policy Guides Manual, Sec. 460.200
    4. ↑ Drugs.com: suprofen ophthalmic


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