List of psychoactive plants

Salvia divinorum, a dissociative hallucinogenic sage

A list of plants that are used as psychoactive drugs. Some of them have been used entheogenically for millennia. The plants are listed according to the substances they contain.

Cannabis

Cannabis plant

Cannabis (Marijuana) is a popular psychoactive plant that is often used medically and recreationally. The psychoactive substance in Cannabis, THC, is unique in that it contains no nitrogen and is not an indole, tryptamine, phenethylamine, anticholinergic (deliriant), or a dissociative drug. Cannabis plants tend to vary, with different strains producing dynamic balances of cannabinoids (THC, CBD, etc.) yielding markedly different effects. Popular strains are often hybrids of Cannabis sativa and Cannabis indica.

Some universities and research firms currently study the medicinal effects of cannabis. Many jurisdictions have laws regulating or prohibiting the sale and use of medical and recreational cannabis.

Tryptamines

DMT Molecule in 2D
DMT Molecule in 3D

Many of the psychedelic plants contain dimethyltryptamine (DMT), which is either snorted (Virola, Yopo snuffs), vaporized, or drunk with MAOIs (Ayahuasca). It cannot simply be eaten as it is not orally active without an MAOI and it needs to be extremely concentrated to be vaporized.

Acanthaceae

Species, Alkaloid content, where given, refers to dried material

Aceraceae

  • Acer saccharinum (Silver Maple Tree) was found to contain the indole alkaloid gramine (not active and extremely toxic) 0.05% in the leaves, so it is possible that other members of this plant family contain active compounds.[1]

Aizoaceae

  • Delosperma acuminatum, DMT, 5-MEO-DMT[2]
  • Delosperma cooperi, DMT, 5-MEO-DMT[2]
  • Delosperma ecklonis, DMT[2]
  • Delosperma esterhuyseniae, DMT[2]
  • Delosperma hallii, 5-MEO-DMT[2]
  • Delosperma harazianum, DMT, 5-MEO-DMT[2]
    Delosperma harazianum
    Shibam, DMT[2]
  • Delosperma hirtum, DMT[2]
    Delosperma hallii
    aff. litorale
  • Delosperma lydenbergense, DMT, 5-MEO-DMT[2]
  • Delosperma nubigenum, 5-MEO-DMT[2]
  • Delosperma pageanum, DMT, 5-MEO-DMT[2]
  • Delosperma pergamentaceum, Traces of DMT[2]
  • Delosperma tradescantioides, DMT[2]

Apocynaceae

Fabaceae (Leguminosae)

1,2,3,4-Tetrahydro-6-methoxy-2,9-dimethyl-beta-carboline, Plant,[47] 1,2,3,4-Tetrahydro-6-methoxy-2-methyl-beta-carboline, Plant,[44] 5-Methoxy-N,N-dimethyltryptamine, Bark,[44] 5-Methoxy-N-methyltryptamine, Bark,[44] Bufotenin, plant,[44] beans,[43] Bufotenin N-oxide, Fruit,[44] beans,[43] N,N-Dimethyltryptamine-oxide, Fruit[44][48]

Caesalpinioideae subfamily

Malpighiaceae

Myristicaceae

Ochnaceae

Ochnaceae

Poaceae (Gramineae)

Some Graminae (grass) species contain gramine, which can cause brain damage, other organ damage, central nervous system damage and death in sheep.[69]

Polygonaceae

  • Erigonum sp.: DMT

Punicaceae

  • Punica granatum "DMT in root cortex;"[63] The dried stem and root bark of the tree contain about 0.4-0.9% alkaloids.[73]

Rubiaceae

Rutaceae[76][77]

  • Dictyoloma incanescens, 5-MeO-DMT in leaves,[67] 0.04% 5-MeO-DMT in bark[55]
  • Dutaillyea drupacea, > 0.4% 5-MeO-DMT in leaves[32]
  • Dutaillyea oreophila, 5-MeO-DMT in leaves
  • Tetradium ruticarpum(syn. Evodia rutaecarpa), 5-MeO-DMT in leaves, fruit and roots
  • Limonia acidissima, 5-MeO-DMT in stems
  • Euodia leptococca (formerly Melicope), 0.2% total alkaloids, 0.07% 5-MeO-DMT; 5-MeO-DMT in leaves and stems, also "5-MeO-DMT-Oxide and a beta-carboline"[62]
  • Pilocarpus organensis, 5-MeO-DMT in leaves
  • Vepris ampody, Up to 0.2% DMT in leaves and branches[55]
  • Zanthoxylum arborescens, DMT in leaves
  • Zanthoxylum procerum, DMT in leaves

Urticaceae

Phenethylamines

Species, Alkaloid Content (Fresh) - Alkaloid Content (Dried)

  • Coryphantha contains various PhEAs alkaloids including Macromerine Coryphanthine MethOxy-Candicine Corypalmine NMetCorypalmine and like compounds. [78] [79]
Macromerine meta(ortho(CH3O)2)C6H3-CH(OH)-CH2N(CH3)2 , m(o(CH3O)2)C6H3-CH[O(-)]-CH2N(+)(CH3)3
p(-)O-C6H5-CH(H,OH,OCH3)CH2N(+)(CH3)3 and C6H5-CH[O(-)]-CH2N(+)(CH3)3
Coryphanthine C6H5-CH(OCH3)-CH2N(+)(CH3)3 , MeO-Candicine paraCH3O-C6H4-CH2CH2-N(+)(CH3)3

Beta-carbolines

Harmaline, a Beta-carboline

Beta-carbolines are "reversible" MAO-A inhibitors. They are found in some plants used to make Ayahuasca. In high doses the harmala alkaloids are somewhat hallucinogenic on their own. β-carboline is a benzodiazepine receptor inverse agonist and can therefore have convulsive, anxiogenic and memory enhancing effects.[91]

Apocynaceae

Bignoniaceae

  • Newbouldia laevis, Harman

Calycanthaceae

Chenopodiaceae

Combretaceae

Cyperaceae

  • Carex brevicollis, Harmine, etc.
  • Carex parva, Beta-carbolines[92]

Elaeagnaceae

Gramineae

Lauraceae

  • Nectandra megapotamica, Beta-carbolines[92]

Leguminosae

Loganiaceae

Malpighiaceae

Myristicaceae

Ochnaceae

Palmae

  • Plectocomiopsis geminiflora, Beta-carbolines[92]

Papaveraceae

Passifloraceae

Polygonaceae

  • Calligonum minimum, Beta-carbolines[92]
  • Leptactinia densiflora, Leptaflorine, etc.
  • Ophiorrhiza japonica, Harman
  • Pauridiantha callicarpoides, Harman
  • Pauridiantha dewevrei, Harman
  • Pauridiantha lyalli, Harman
  • Pauridiantha viridiflora, Harman
  • Simira klugei, Harman
  • Simira rubra, Harman

Rubiaceae

Rutaceae

Sapotaceae

Simaroubaceae

Solanaceae

Symplocaceae

Tiliaceae

  • Grewia mollis, Beta-carbolines[92]

Zygophyllaceae

Plants containing other psychoactive substances

Substance Plant Comment
Asarone Acorus calamus Asarone
Yohimbine Alchornea floribunda Yohimbine
Arecoline Areca catechu Areca nut or betel
Unknown

Argemone mexicana

Used by Chinese residents of Mexico during the early 20th century as a legal substitute for opium and currently smoked as a marijuana substitute.

Ergine

Argyreia nervosa (Hawaiian Baby Woodrose)

Seeds contain high amounts of ergine (also known as LSA, lysergamide, or lysergic acid amide), often 50-150X the amounts found in Ipomoea violacea.
Thujone Artemisia absinthium Additive to absinthe. Also called "wormwood"
Tropane alkaloids Atropa belladonna Deadly nightshade
Tropane alkaloids Brugmansia Angel's trumpets
Unknown

Calea zacatechichi

Produces vivid dreams after smoking. It is also employed by the Chontal people as a medicinal herb against gastrointestinal disorders, and is used as an appetizer, cathartic anti-dysentery remedy, and as a fever-reducing agent. Its psychedelic properties do not become apparent until the user is asleep.
Caffeine Camellia sinensis Tea leaves, tea, native to Asia

Cathinone

Catha edulis

Khat[101]
Vincristine Catharanthus roseus Catharanthus roseus is (perhaps unpleasantly) "hallucinogenic."[102]
Unknown Cestrum nocturnum Night-blooming jasmine
Caffeine Coffea arabica Coffee beans, coffee, native to Africa
Caffeine Cola Cola or kola nut, traditional additive to cola, native to Africa
Unknown

Coleus

Unknown

Bulbocapnine

Corydalis solida, cava

Bulbocapnine, Nantenine, Tetrahydropalmatine
Tropane alkaloids Datura Thorn apple, devil's trumpets, loco weed, Jimson weed
Cytisine Dermatophyllum Mescal bean
Unknown Desfontainia spinosa Causes visions[103]
Nicotine Duboisia hopwoodii Pituri
Unknown Entada rheedii African dream herb
Ephedrine Ephedra sinica Ephedra
Cocaine Erythroxylum coca Coca. Widely used illegal stimulant, produces hallucination in overdose, native to South America
Unknown Fittonia albivenis Nerve or mosaic plant
Unknown

Foeniculum vulgare

Unknown

Himbacine

Galbulimima belgraveana Galbulimima belgraveana is rich in alkaloids and twenty-eight alkaloids have been isolated including himbacine.

Glaucine

Glaucium flavum

Glaucine
Unknown Heimia myrtifolia Auditory
Unknown Heimia salicifolia Auditory[104][104]
Lobeline Hippobroma longiflora Star of Bethlehem
Myrcene Humulus lupulus Hops
Hyperforin Hypericum perforatum Saint John's wort
Tropane alkaloids Hyoscyamus Henbane
Unknown Ilex guayusa Ilex guayusa is used as an additive to some versions of Ayahuasca. According to the Ecuadorian indigenous, it is also slightly hallucinogenic on its own, when drunk in high enough quantities.
Ergine

Ipomoea tricolor & Ipomoea violacea

Ergine in seeds; up to 0.12% total[105]
Unknown Justicia pectoralis Unknown
Lactucarium

Lactuca virosa

Lactucarium

Lagochilin

Lagochilus inebrians Lagochilin is thought to be responsible for the sedative, hypotensive and hemostatic effects of this plant.

Pukateine

Laurelia novae-zelandiae

Pukateine

Leonurine

Leonotis leonurus

Both leaves and flowers (where most concentrated) contain Leonurine. (Effects reminiscent of marijuana)

Leonurine

Leonotis nepetifolia

Both leaves and flowers (where most concentrated) contain Leonurine. (Effects reminiscent of marijuana)
Lobeline Lobelia inflata Indian tobacco
Unknown

Magnolia virginiana

[106]
Tropane alkaloids Mandragora officinarum Mandrake
Ergine Some Mirabilis spp. Possibly contains ergine
Mitragynine Mitragyna speciosa Kratom
Myristicin Myristica fragrans Nutmeg
Aporphine Nelumbo nucifera Sacred lotus
Nepetalactone Nepeta cataria Catnip
Nicotine Nicotiana tabacum Tobacco. Can cause hallucination in very large doses

Aporphine

Nymphaea caerulea

Blue lotus or lily. Recent studies have shown Nymphaea caerulea to have psychedelic properties, and may have been used as a sacrament in ancient Egypt and certain ancient South American cultures. Dosages of 5 to 10 grams of the flowers induces slight stimulation, a shift in thought processes, enhanced visual perception, and mild closed-eye visuals. Nymphaea caerulea is related to, and possesses similar activity as Nelumbo nucifera, the Sacred Lotus. Both Nymphaea caerulea and Nelumbo nucifera contain the alkaloids nuciferine and apomorphine, which have been recently isolated by independent labs.

These psychoactive effects make Nymphaea caerulea a likely candidate (among several) for the lotus plant eaten by the mythical Lotophagi in Homer's Odyssey.

Used in aromatherapy, Nymphaea caerulea is purported to have a "divine" essence, bringing euphoria, heightened awareness and tranquility.

Other sources cite anti-spasmodic and sedative, purifying and calming properties.

Heliamine Pachycereus pringlei Largest cactus in the world. Heliamine bears some similarities to mescaline
Ginsenosides Panax Ginseng
Morphine Papaver somniferum Opium. Widely used analgesic, native to the Old World
Chrysin Passiflora Passion flower
Yohimbine Pausinystalia johimbe Yohimbe
Unknown Pedicularis densiflora Indian warrior

Kavalactones

Piper methysticum

Kavalactones
Ergine Rivea corymbosa Seeds contain ergine, lysergol, and turbicoryn; lysergic acid alkaloids up to 0.03%[107]

Salvinorin A

Salvia divinorum

Salvinorin A, 0.89-3.87 mg/g, also Salvinorin B and Salvinorin C[108]
Mesembrine Sceletium tortuosum Kanna
Baicalein Scutellaria Skullcaps
Unknown

Silene capensis

Produces vivid dreams after smoking.
Unknown

Tagetes lucida

Anethole, Chavicol, Coumarin, Estragole, Isorhamnetin, Methyleugenol, Quercitin

Ibogaine

Tabernanthe iboga

Ibogaine in root bark[109]

Ibogaine

Tabernanthe orientalis

Ibogaine in root leaves[109]

Ibogaine

Tabernanthe pubescens

Ibogaine and similar alkaloids[109]

Ibogaine

Tabernaemontana sp.

Ibogaine[109]
Caffeine Theobroma cacao Cocoa or cacao bean, chocolate, native to the Americas

Ibogaine

Trachelospermum jasminoides

Ibogaine[110]
Damianin

Turnera diffusa

Damianin
Actinidine Valeriana officinalis Valerian
Vincamine Vinca minor Vincamine
Voacangine Voacanga africana Voacangine is similar to ibogaine
Unknown Zornia latifolia Zornia latifolia is mentioned in Food of the Gods as "an hallucinogenic substitute for cannabis". It is nicknamed Maconha brava because locals use it as a cannabis substitute.

See also

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Bibliography

  • Al Zarouni, Yousif (2015). The Effects of Khat (Catha Edulis). London: Yousif Al Zarouni.
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