Vincamine

Vincamine

Clinical data
Trade names	Oxybral SR
AHFS/Drugs.com	International Drug Names
ATC code	C04AX07 (WHO)
Identifiers
IUPAC name (3α,14β,16α)-14,15-Dihydro-14-hydroxyeburnamenine-14-carboxylic acid methyl ester or Methyl (15R,17S,19R)-15-ethyl-17-hydroxy-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2(7),3,5,8(18)-tetraene-17-carboxylate
CAS Number	1617-90-9 Y
PubChem CID	15376
IUPHAR/BPS	349
ChemSpider	14635 N
UNII	996XVD0JHT
KEGG	D08677 Y
ChEMBL	CHEMBL1165342 N
ECHA InfoCard	100.015.070
Chemical and physical data
Formula	C21H26N2O3
Molar mass	354.45 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(OC)[C@]3(O)n1c4c(c2ccccc12)CCN5CCC[C@](C3)(CC)[C@@H]45
InChI InChI=1S/C21H26N2O3/c1-3-20-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(17(15)18(20)22)21(25,13-20)19(24)26-2/h4-5,7-8,18,25H,3,6,9-13H2,1-2H3/t18-,20+,21+/m1/s1 N Key:RXPRRQLKFXBCSJ-GIVPXCGWSA-N N
NY (what is this?)  (verify)

Vincamine is a monoterpenoid indole alkaloid found in the leaves of Vinca minor (lesser periwinkle), comprising about 25-65% of its indole alkaloids by weight. It can also be synthesized from related alkaloids.^[1]

Uses

It is sold in Europe as a prescription medicine for improving cerebral blood flow, brain metabolism, and increasing the firing rate of locus coeruleus-noradrenergic system. Vincamine is a peripheral vasodilator that increases blood flow to the brain. Generic drugs containing vincamine exist in specific regions. Most common drug preparations are in the sustained release tablet forms.

See also

• Vinpocetine

References

External links

• "Vincamine MSDS" (pdf).
• Chemical Selection Working Group. "Vincamine - 1617-90-9" (PDF). Summary of Data for Chemical Selection. NIH - United States National Institutes of Health. Archived from the original (pdf) on 2011-10-21. Retrieved 2007-04-23.