Histidine methyl ester

Histidine methyl ester
Names
	Other names Methyl L-histidinate, HME
Identifiers
CAS Number	1499-46-3; 5619-04-5; 7389-87-9;
3D model (JSmol)	Interactive image;
Beilstein Reference	957974
ChEBI	CHEBI:70961;
ChemSpider	83857;
EC Number	216-109-3
UNII	9IHZ1723UE;
	InChI InChI=1S/C7H11N3O2/c1-12-7(11)6(8)2-5-3-9-4-10-5/h3-4,6H,2,8H2,1H3,(H,9,10)/t6-/m0/s1 Key: BXRMEWOQUXOLDH-LURJTMIESA-N;
	SMILES COC(=O)[C@H](Cc1c[nH]cn1)N;
Properties
Chemical formula	C7H11N3O2
Molar mass	169.18 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Histidine methyl ester (HME) is an irreversible histidine decarboxylase inhibitor.^[1]^[2]^[3] It is the methyl ester of histidine.

References

↑ Lane, Roger S; Manning, James M; Snell, Esmond E (2002). "Histidine decarboxylase of lactobacillus 30a: inactivation and active-site labeling by L-histidine methyl ester". Biochemistry. 15 (19): 4180. doi:10.1021/bi00664a008. PMID 963031.
↑ Alston, Theodore A; Abeles, Robert H (2002). "Reaction of Lactobacillus histidine decarboxylase with L-histidine methyl ester". Biochemistry. 26 (13): 4082. doi:10.1021/bi00387a051. PMID 3651438.
↑ Komori, H; Nitta, Y; Ueno, H; Higuchi, Y (2012). "Structural Study Reveals That Ser-354 Determines Substrate Specificity on Human Histidine Decarboxylase". The Journal of Biological Chemistry. 287 (34): 29175–83. doi:10.1074/jbc.M112.381897. PMC 3436558. PMID 22767596.

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