RTI-171
(–)-2β-(3-Methylisoxazol-5-yl)-3β-(p-tolyl)tropane (RTI-4229-171) is a phenyltropane derivative which acts as a selective dopamine reuptake inhibitor, with a relatively slow onset of action and short duration of effects found in animal studies.[1] However, other studies have shown it to have the most pronounced effects in terms of speed of onset and rate of stimulation among many differing phenyltropanes.[2]
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| Chemical and physical data | |
| Formula | C19H24N2O |
| Molar mass | 296.414 g·mol−1 |
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See also
References
- Kimmel HL, Carroll FI, Kuhar MJ (December 2001). "Locomotor stimulant effects of novel phenyltropanes in the mouse". Drug and Alcohol Dependence. 65 (1): 25–36. doi:10.1016/S0376-8716(01)00144-2. PMID 11714587.
- Kimmel, Heather L.; O'Connor, Joann A.; Carroll, F. Ivy; Howell, Leonard L. (2007). "Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys". Pharmacology Biochemistry and Behavior. 86 (1): 45–54. doi:10.1016/j.pbb.2006.12.006. ISSN 0091-3057. PMC 1850383. PMID 17258302.
| 2-Carboxymethyl Esters | |
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| (3,4-Disubstituted Phenyl)-tropanes | |
| Arylcarboxy | |
| Carboxyalkyl | |
| Acyl | |
| β,α Stereochemistry | |
| α,β Stereochemistry | |
| Heterocycles: 3-Substituted-isoxazol-5-yl | |
| Heterocycles: 3-Substituted-1,2,4-oxadiazole | |
| N-alkyl | |
| N-replaced (S,O,C) | |
| Irreversible |
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| Nortropanes (N-demethylated) | |
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