MARK4

MARK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5ES1
Identifiers
Aliases	MARK4, MARK4L, MARK4S, MARKL1, MARKL1L, PAR-1D, microtubule affinity regulating kinase 4
External IDs	OMIM: 606495 MGI: 1920955 HomoloGene: 57146 GeneCards: MARK4
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	45,305,284 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	19,458,821 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • microtubule binding; • kinase activity; • protein serine/threonine kinase activity; • tau-protein kinase activity; • ubiquitin binding; • GO:0001948 protein binding; • gamma-tubulin binding; • ATP binding; • tau protein binding;
Cellular component	• ciliary basal body; • cytosol; • centrosome; • microtubule cytoskeleton; • neuron projection; • cytoskeleton; • cell projection; • cytoplasm; • microtubule organizing center; • gamma-tubulin complex; • dendrite; • midbody;
Biological process	• phosphorylation; • positive regulation of programmed cell death; • nervous system development; • protein phosphorylation; • microtubule bundle formation; • cell cycle; • cell division; • establishment of cell polarity; • microtubule cytoskeleton organization; • cell projection organization; • ciliary basal body docking; • intracellular signal transduction; • cilium organization; • positive regulation of cilium assembly; • regulation of centrosome cycle; • positive regulation of protein localization to centrosome;
	Sources:Amigo / QuickGO
Orthologs
	57787
	232944
	ENSG00000007047
	ENSMUSG00000030397
	Q96L34
	Q8CIP4
	NM_001199867; NM_031417
	NM_172279; NM_001368427
	NP_001186796; NP_113605
	NP_758483; NP_001355356
	Wikidata
View/Edit Human	View/Edit Mouse

MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene.[5][6][7] MARK4 belongs to the family of serine/threonine kinases that phosphorylate microtubule-associated proteins (MAP) causing their detachment from microtubules.[8] Detachment thereby increases microtubule dynamics and facilitates a number of cell activities including cell division, cell cycle control, cell polarity determination, and cell shape alterations.[9]

There are four members of the MARK protein family, MARK1-4, which are highly conserved. MARK4 kinase has been shown to be involved in microtubule organization in neuronal cells. Levels of MARK4 are elevated in Alzheimer's disease and may contribute to the pathological phosphorylation of tau in this disease.

Interactions

MARK4 has been shown to interact with USP9X[10] and Ubiquitin C.[10]

References

GRCh38: Ensembl release 89: ENSG00000007047 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030397 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kato T, Satoh S, Okabe H, Kitahara O, Ono K, Kihara C, Tanaka T, Tsunoda T, Yamaoka Y, Nakamura Y, Furukawa Y (Apr 2001). "Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis". Neoplasia. 3 (1): 4–9. doi:10.1038/sj.neo.7900132. PMC 1505019. PMID 11326310.
Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (April 1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell. 89 (2): 297–308. doi:10.1016/S0092-8674(00)80208-1. PMID 9108484.
"Entrez Gene: MARK4 MAP/microtubule affinity-regulating kinase 4".
Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (April 1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell. 89 (2): 297–308. doi:10.1016/s0092-8674(00)80208-1. PMID 9108484.
Naz F, Anjum F, Islam A, Ahmad F, Hassan MI (November 2013). "Microtubule affinity-regulating kinase 4: structure, function, and regulation". Cell Biochemistry and Biophysics. 67 (2): 485–99. doi:10.1007/s12013-013-9550-7. PMID 23471664.
Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR (April 2008). "Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains" (PDF). The Biochemical Journal. 411 (2): 249–60. doi:10.1042/BJ20080067. PMID 18254724.

Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
Beghini A, Magnani I, Roversi G, Piepoli T, Di Terlizzi S, Moroni RF, Pollo B, Fuhrman Conti AM, Cowell JK, Finocchiaro G, Larizza L (May 2003). "The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines". Oncogene. 22 (17): 2581–91. doi:10.1038/sj.onc.1206336. PMID 12735302.
Trinczek B, Brajenovic M, Ebneth A, Drewes G (February 2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". The Journal of Biological Chemistry. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (March 2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". The Journal of Biological Chemistry. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Schneider A, Laage R, von Ahsen O, Fischer A, Rossner M, Scheek S, Grünewald S, Kuner R, Weber D, Krüger C, Klaussner B, Götz B, Hiemisch H, Newrzella D, Martin-Villalba A, Bach A, Schwaninger M (March 2004). "Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4". Journal of Neurochemistry. 88 (5): 1114–26. doi:10.1046/j.1471-4159.2003.02228.x. PMID 15009667.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (March 2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Molecular & Cellular Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000007047 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030397 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11326310-5] Kato T, Satoh S, Okabe H, Kitahara O, Ono K, Kihara C, Tanaka T, Tsunoda T, Yamaoka Y, Nakamura Y, Furukawa Y (Apr 2001). "Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis". Neoplasia. 3 (1): 4–9. doi:10.1038/sj.neo.7900132. PMC 1505019. PMID 11326310.

[pmid9108484-6] Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (April 1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell. 89 (2): 297–308. doi:10.1016/S0092-8674(00)80208-1. PMID 9108484.

[entrez-7] "Entrez Gene: MARK4 MAP/microtubule affinity-regulating kinase 4".

[8] Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (April 1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell. 89 (2): 297–308. doi:10.1016/s0092-8674(00)80208-1. PMID 9108484.

[9] Naz F, Anjum F, Islam A, Ahmad F, Hassan MI (November 2013). "Microtubule affinity-regulating kinase 4: structure, function, and regulation". Cell Biochemistry and Biophysics. 67 (2): 485–99. doi:10.1007/s12013-013-9550-7. PMID 23471664.

[pmid18254724-10] Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR (April 2008). "Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains" (PDF). The Biochemical Journal. 411 (2): 249–60. doi:10.1042/BJ20080067. PMID 18254724.

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

MARK4

Interactions

References

Further reading