FASTK

FASTK
Identifiers
Aliases	FASTK, Fastk, 0610011K02Rik, 610011K02Rik, FAST, Fas activated serine/threonine kinase
External IDs	OMIM: 606965 MGI: 1913837 HomoloGene: 4884 GeneCards: FASTK
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	151,080,866 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	24,445,287 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• kinase activity; • transferase activity; • nucleotide binding; • protein serine/threonine kinase activity; • protein kinase activity; • GO:0001948 protein binding; • Fas-activated serine/threonine kinase activity; • ATP binding; • RNA binding;
Cellular component	• mitochondrion; • mitochondrial matrix;
Biological process	• apoptotic signaling pathway; • protein phosphorylation; • regulation of RNA splicing; • phosphorylation; • apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	10922
	66587
	ENSG00000164896
	ENSMUSG00000028959
	Q14296
	Q9JIX9
	NM_001258461; NM_006712; NM_033015
	NM_023229
	NP_001245390; NP_006703; NP_148936
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.[5][6][7]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates the apoptosis-promoting nuclear RNA-binding protein TIA1. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.[7]

References

GRCh38: Ensembl release 89: ENSG00000164896 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028959 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Tian Q, Taupin J, Elledge S, Robertson M, Anderson P (Sep 1995). "Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis". J Exp Med. 182 (3): 865–74. doi:10.1084/jem.182.3.865. PMC 2192163. PMID 7544399.
Li W, Simarro M, Kedersha N, Anderson P (Dec 2004). "FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression". Mol Cell Biol. 24 (24): 10718–32. doi:10.1128/MCB.24.24.10718-10732.2004. PMC 533970. PMID 15572676.
"Entrez Gene: FASTK Fas-activated serine/threonine kinase".

Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Li W, Kedersha N, Chen S, et al. (2004). "FAST is a BCL-X(L)-associated mitochondrial protein". Biochem. Biophys. Res. Commun. 318 (1): 95–102. doi:10.1016/j.bbrc.2004.03.188. PMID 15110758.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Izquierdo JM, Valcárcel J (2007). "Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing". J. Biol. Chem. 282 (3): 1539–43. doi:10.1074/jbc.C600198200. PMID 17135269.
Simarro M, Mauger D, Rhee K, et al. (2007). "Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing". Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11370–5. doi:10.1073/pnas.0704964104. PMC 2040905. PMID 17592127.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164896 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028959 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7544399-5] Tian Q, Taupin J, Elledge S, Robertson M, Anderson P (Sep 1995). "Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis". J Exp Med. 182 (3): 865–74. doi:10.1084/jem.182.3.865. PMC 2192163. PMID 7544399.

[pmid15572676-6] Li W, Simarro M, Kedersha N, Anderson P (Dec 2004). "FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression". Mol Cell Biol. 24 (24): 10718–32. doi:10.1128/MCB.24.24.10718-10732.2004. PMC 533970. PMID 15572676.

[entrez-7] "Entrez Gene: FASTK Fas-activated serine/threonine kinase".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

FASTK

References

Further reading