MAP2K4

Dual-specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene.[5]

MAP2K4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ALN, 3ALO, 3VUT
Identifiers
Aliases	MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, mitogen-activated protein kinase kinase 4
External IDs	OMIM: 601335 MGI: 1346869 HomoloGene: 48159 GeneCards: MAP2K4
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p12 Start 12,020,829 bp[1] End 12,143,830 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 40.53 cM Start 65,688,243 bp[2] End 65,788,297 bp[2]
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • kinase activity • GO:0001948 protein binding • protein tyrosine kinase activity • ATP binding • MAP kinase kinase activity • JUN kinase kinase activity • protein serine/threonine kinase activity • mitogen-activated protein kinase kinase kinase binding Cellular component • cytoplasm • cell nucleus • dendrite cytoplasm • cytosol • perikaryon • axon Biological process • phosphorylation • MAPK cascade • protein phosphorylation • cellular response to mechanical stimulus • response to wounding • peptidyl-tyrosine phosphorylation • signal transduction • negative regulation of motor neuron apoptotic process • apoptotic process • cell growth involved in cardiac muscle cell development • cellular response to sorbitol • positive regulation of smooth muscle cell apoptotic process • JNK cascade • positive regulation of protein phosphorylation • positive regulation of neuron apoptotic process • positive regulation of DNA replication • activation of JUN kinase activity • positive regulation of apoptotic process • positive regulation of nitric-oxide synthase biosynthetic process • regulation of mitotic cell cycle • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process • activation of MAPK activity • Fc-epsilon receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6416	26398
Ensembl	ENSG00000065559	ENSMUSG00000033352
UniProt	P45985	P47809
RefSeq (mRNA)	NM_001281435 NM_003010	NM_009157 NM_001316367 NM_001316368 NM_001316369 NM_001362739 NM_001362740
RefSeq (protein)	NP_001268364 NP_003001	NP_001303296 NP_001303297 NP_001303298 NP_033183 NP_001349668 NP_001349669
Location (UCSC)	Chr 17: 12.02 – 12.14 Mb	Chr 11: 65.69 – 65.79 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

MAP2K4 encodes a dual-specificity kinase that belongs to the Ser/Thr protein kinase family. MAP2K4 phosphorylates MAP kinases in response to various environmental stresses or mitogenic stimuli. MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38 are substrates for MAP2K4, but MAPK1/ERK2 and MAPK3/ERK1 are not phosphorylated by MAP2K4. MAP2K4 is phosphorylated and activated by MAP3K1/MEKK1. Knockout mouse studies suggest roles for MAP2K4 in mediating T cell development and liver organogenesis.[6]