CDKL2

CDKL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AAA, 4BBM
Identifiers
Aliases	CDKL2, KKIAMRE, P56, cyclin dependent kinase like 2
External IDs	OMIM: 603442 MGI: 1858227 HomoloGene: 55793 GeneCards: CDKL2
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	75,630,716 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	92,043,883 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • protein kinase activity; • nucleotide binding; • protein serine/threonine kinase activity; • ATP binding; • kinase activity; • cyclin-dependent protein serine/threonine kinase activity;
Cellular component	• cytoplasm; • centrosome; • cell nucleus;
Biological process	• protein phosphorylation; • sex differentiation; • phosphorylation; • signal transduction; • regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	8999
	53886
	ENSG00000138769
	ENSMUSG00000029403
	Q92772
	Q9QUK0
	NM_003948; NM_001330724
	NM_001276315; NM_016912; NM_177270
	NP_001317653; NP_003939
	NP_001263244; NP_058608; NP_796244
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.[5][6]

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.[6]

References

GRCh38: Ensembl release 89: ENSG00000138769 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029403 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Taglienti CA, Wysk M, Davis RJ (Feb 1997). "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE". Oncogene. 13 (12): 2563–74. PMID 9000130.
"Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)".

External links

Human CDKL2 genome location and CDKL2 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q92772 (Cyclin-dependent kinase-like 2) at the PDBe-KB.

Marracci GH, Marquardt WE, Strehlow A, et al. (2006). "Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck)". Biochem. Biophys. Res. Commun. 344 (3): 963–971. doi:10.1016/j.bbrc.2006.03.172. PMID 16631599.
Sarkar SN, Peters KL, Elco CP, et al. (2004). "Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling". Nat. Struct. Mol. Biol. 11 (11): 1060–1067. doi:10.1038/nsmb847. PMID 15502848.
Tao J, Van Esch H, Hagedorn-Greiwe M, et al. (2005). "Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation". Am. J. Hum. Genet. 75 (6): 1149–1154. doi:10.1086/426460. PMC 1182152. PMID 15499549.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
"Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
Marcilla A, Rivero-Lezcano OM, Agarwal A, Robbins KC (1995). "Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors". J. Biol. Chem. 270 (16): 9115–9120. doi:10.1074/jbc.270.16.9115. PMID 7721825.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138769 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029403 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9000130-5] Taglienti CA, Wysk M, Davis RJ (Feb 1997). "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE". Oncogene. 13 (12): 2563–74. PMID 9000130.

[entrez-6] "Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

CDKL2

References

External links

Further reading