Irazepine
Irazepine (Ro 7-1986/1) is a benzodiazepine derivative containing isothiocyanate functional group.[1] It is a non-competitive benzodiazepine binding site antagonist.[2] Irazepine and other alkylating benzodiazepine, kenazepine, bind to brain benzodiazepine receptors in a non-competitive (covalent) fashion in vitro, and may exert a long-lasting anticonvulsant effect.[3]
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| Formula | C18H13ClFN3OS |
| Molar mass | 373.83 g·mol−1 |
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References
- Ganellin CR, Triggle DJ, eds. (1999). Dictionary of Pharmacological Agents (1st ed.). London: Chapman & Hall. ISBN 9780412466304.
- Hall IK, Morton JM (1999). Concise Dictionary of Pharmacological Agents Properties and Synonyms. Dordrecht: Springer Netherlands. p. 156. ISBN 978-94-011-4439-1.
- Williams EF, Rice KC, Mattson M, Paul SM, Skolnick P (April 1981). "In vivo effects of two novel alkylating benzodiazepines, irazepine and kenazepine". Pharmacology, Biochemistry, and Behavior. 14 (4): 487–91. doi:10.1016/0091-3057(81)90307-5. PMID 7232472.
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