Ampelopsin

Ampelopsin, also known as dihydromyricetin and DHM, when purported as an effective ingredient in supplements and other tonics, is a flavanonol, a type of flavonoid. It is found in the Ampelopsis species japonica, megalophylla, and grossedentata; Cercidiphyllum japonicum; Hovenia dulcis; Rhododendron cinnabarinum; some Pinus species; and some Cedrus species,[1] as well as in Salix sachalinensis.[2]

For other uses, see Ampelopsin (compound).
Ampelopsin
Names
IUPAC name
(2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
Other names
Dihydromyricetin, Ampeloptin,(+)-Ampelopsin,(+)-Dihydromyricetin
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
UNII
Properties
C15H12O8
Molar mass 320.253 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Hovenia dulcis has been used in traditional Japanese, Chinese, and Korean medicines to treat fever, parasitic infection, as a laxative, and a treatment of liver diseases, and as a hangover treatment.[3] Methods have been developed to extract ampelopsin from it at large scales, and laboratory research has been conducted with the compound to see if it might be useful as a drug in any of the conditions for which the parent plant has been traditionally used.[3]

Scientific peer-reviewed research

In a trial of 60 patients with "nonalcoholic fatty liver disease," dihydromyricetin improved glucose and lipid metabolism and yielded potentially beneficial anti-inflammatory effects.[4]

In a study wherein the subjects were rats, researchers demonstrated "pharmacological properties of dihydromyricetin consistent with those expected to underlie successful medical treatment of alcohol use disorders; therefore dihydromyricetin is a therapeutic candidate."[5]

"Structurally, due to the highly hydrophilic character, dihydromyricetin shows poor bioavailability and significantly limits its potential medicinal applications."[6] "In pharmacology, bioavailability [...] is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation."[7]

As they pertain to dihydromyricetin, additional research is required before claims of human efficacy and application, necessary dosage, and solutions to poor bioavailability, are met with scientific validation.

References
  1. Zhou, Jiaju; Xie, Guirong; Yan, Xinjian (2011-02-21). Encyclopedia of Traditional Chinese Medicines – Molecular Structures, Pharmacological Activities, Natural Sources and Applications: Vol. 1: Isolated Compounds A-C. Springer Science & Business Media. ISBN 978-3-642-16735-5.
  2. Tahara, Satoshi (June 23, 2007). "A Journey of Twenty-Five Years through the Ecological Biochemistry of Flavonoids". Bioscience, Biotechnology, and Biochemistry. 71 (6): 1387–1404. doi:10.1271/bbb.70028. ISSN 0916-8451. PMID 17587669.
  3. Hyun, Tae; Eom, Seung; Yu, Chang; Roitsch, Thomas (2010). "Hovenia dulcis– An Asian Traditional Herb". Planta Medica. 76 (10): 943–949. doi:10.1055/s-0030-1249776. ISSN 0032-0943. PMID 20379955.
  4. Chen, Shihui; Zhao, Xiaolan; Wan, Jing; Ran, Li; Qin, Yu; Wang, Xiaofang; Gao, Yanxiang; Shu, Furong; Zhang, Yong; Liu, Peng; Zhang, Qianyong; Zhu, Jundong; Mi, Mantian (2015). "Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial". Pharmacological Research. 99: 74–81. doi:10.1016/j.phrs.2015.05.009. ISSN 1043-6618. PMID 26032587.
  5. Yi Shen, A. Kerstin Lindemeyer, Claudia Gonzalez, Xuesi M. Shao, Igor Spigelman, Richard W. Olsen & Jing Liang (2012). "Dihydromyricetin as a novel anti-alcohol intoxication medication". The Journal of Neuroscience. 32 (1): 390–401. doi:10.1523/JNEUROSCI.4639-11.2012. PMC 3292407. PMID 22219299.CS1 maint: multiple names: authors list (link)
  6. Li, Hongliang; Li, Qisheng; Liu, Zhaowen; Yang, Kai; Chen, Zhixi; Cheng, Qilai; Wu, Longhuo (2017). "The Versatile Effects of Dihydromyricetin in Health". Evidence-based Complementary and Alternative Medicine : ECAM. 2017: 1053617. doi:10.1155/2017/1053617. ISSN 1741-427X. PMC 5602609. PMID 28947908.
  7. "Bioavailability - Wikipedia". en.m.wikipedia.org. Retrieved 2020-04-28.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.