FABP6

Fatty acid binding protein 6, ileal (gastrotropin), also known as FABP6, is a protein which in humans is encoded by the FABP6 gene.[5]

FABP6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFABP6, I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP, fatty acid binding protein 6
External IDsOMIM: 600422 MGI: 96565 HomoloGene: 1108 GeneCards: FABP6
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q33.3Start160,187,367 bp[1]
End160,238,735 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2172

16204

Ensembl

ENSG00000170231

ENSMUSG00000020405

UniProt

P51161

P51162

RefSeq (mRNA)

NM_001040442
NM_001130958
NM_001445

NM_008375

RefSeq (protein)

NP_001035532
NP_001124430
NP_001436

NP_032401

Location (UCSC)Chr 5: 160.19 – 160.24 MbChr 11: 43.6 – 43.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene.[5]

References
  1. GRCh38: Ensembl release 89: ENSG00000170231 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020405 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FABP6 fatty acid binding protein 6, ileal (gastrotropin)".

Further reading
  • Börchers T, Hohoff C, Buhlmann C, Spener F (1997). "Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation". Prostaglandins Leukot. Essent. Fatty Acids. 57 (1): 77–84. doi:10.1016/S0952-3278(97)90496-8. PMID 9250612.
  • Fujita M, Fujii H, Kanda T, et al. (1995). "Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein". Eur. J. Biochem. 233 (2): 406–413. doi:10.1111/j.1432-1033.1995.406_2.x. PMID 7588781.
  • Oelkers P, Dawson PA (1995). "Cloning and chromosomal localization of the human ileal lipid-binding protein". Biochim. Biophys. Acta. 1257 (2): 199–202. doi:10.1016/0005-2760(95)00098-w. PMID 7619861.
  • Birkenmeier EH, Rowe LB, Crossman MW, Gordon JI (1995). "Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11". Mamm. Genome. 5 (12): 805–806. doi:10.1007/BF00292019. PMID 7894165.
  • Watanabe K, Hoshi N, Tsuura Y, et al. (1996). "Immunohistochemical distribution of intestinal 15 kDa protein in human tissues". Arch. Histol. Cytol. 58 (3): 303–306. doi:10.1679/aohc.58.303. PMID 8527237.
  • Lücke C, Zhang F, Rüterjans H, et al. (1997). "Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein". Structure. 4 (7): 785–800. doi:10.1016/S0969-2126(96)00086-X. PMID 8805562.
  • Grober J, Zaghini I, Fujii H, et al. (1999). "Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer". J. Biol. Chem. 274 (42): 29749–29754. doi:10.1074/jbc.274.42.29749. PMID 10514450.
  • Seibert C, Harteneck C, Ernst OP, et al. (2000). "Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells". Eur. J. Biochem. 266 (3): 911–916. doi:10.1046/j.1432-1327.1999.00927.x. PMID 10583385.
  • Lücke C, Zhang F, Hamilton JA, et al. (2000). "Solution structure of ileal lipid binding protein in complex with glycocholate". Eur. J. Biochem. 267 (10): 2929–2938. doi:10.1046/j.1432-1327.2000.01307.x. PMID 10806391.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kurz M, Brachvogel V, Matter H, et al. (2003). "Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures". Proteins. 50 (2): 312–328. doi:10.1002/prot.10289. PMID 12486725.
  • Barley NF, Taylor V, Shaw-Smith CJ, et al. (2004). "Human ileal bile acid-binding protein promoter and the effects of CDX2". Biochim. Biophys. Acta. 1630 (2–3): 138–143. doi:10.1016/j.bbaexp.2003.09.008. PMID 14654244.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Landrier JF, Thomas C, Grober J, et al. (2005). "The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors". Biochim. Biophys. Acta. 1735 (1): 41–49. doi:10.1016/j.bbalip.2005.05.002. PMID 15936983.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
  • Bergheim I, Harsch S, Mueller O, et al. (2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers". J. Lipid Res. 47 (1): 42–50. doi:10.1194/jlr.M500215-JLR200. PMID 16237211.
  • Ohmachi T, Inoue H, Mimori K, et al. (2007). "Fatty acid binding protein 6 is overexpressed in colorectal cancer". Clin. Cancer Res. 12 (17): 5090–5095. doi:10.1158/1078-0432.CCR-05-2045. PMID 16951225.
  • Fang C, Dean J, Smith JW (2007). "A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma". Cancer Res. 67 (19): 9039–9046. doi:10.1158/0008-5472.CAN-06-3690. PMID 17909007.
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