Chlorophenylsilatrane
Chlorophenylsilatrane is an extremely toxic organosilicon compound that was used as a rodenticide.
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| Names | |
|---|---|
| IUPAC name
1-(4-Chlorophenyl)-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane | |
| Other names
RS-150 | |
| Identifiers | |
3D model (JSmol) |
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| ChemSpider | |
| ECHA InfoCard | 100.252.129 |
PubChem CID |
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CompTox Dashboard (EPA) |
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| Properties | |
| C12H16ClNO3Si | |
| Molar mass | 285.80 g·mol−1 |
| Hazards | |
| Main hazards | Extremely toxic |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose) |
1.4 mg/kg (rats, oral) 0.9-2.0 mg/kg (mice, oral) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Chlorophenylsilatrane was one of the toxic chemicals studied in the Project Coast.[1]
Toxicity
Chlorophenylsilatrane is a GABA receptor antagonist.[2] It's a rapid acting convulsant, causing convulsions within 1 minute in mice and rats. Death occurred within 5 minutes.[3]
See also
References
- "Project Coast, Part One: The mad doctor and the forgotten rat poison". Toxic Terror.
- Casida, JE; Lawrence, LJ (September 1985). "Structure-activity correlations for interactions of bicyclophosphorus esters and some polychlorocycloalkane and pyrethroid insecticides with the brain-specific t-butylbicyclophosphorothionate receptor". Environmental Health Perspectives. 61: 123–32. doi:10.2307/3430066. PMC 1568750. PMID 2415350.
- Greaves, JH; Redfern, R; Tinworth, H (August 1974). "Laboratory tests of 5-p-chlorophenyl silatrane as a rodenticide". The Journal of Hygiene. 73 (1): 39–43. doi:10.1017/s0022172400023810. PMC 2130561. PMID 4529452.
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