Pindone

Pindone
Names
	IUPAC name 2-(2,2-Dimethyl-1-oxopropyl)indane-1,3-dione
	Other names 2-Pivaloyl-1,3-indandione
Identifiers
CAS Number	83-26-1 ;
3D model (JSmol)	Interactive image;
ChemSpider	6476 ;
ECHA InfoCard	100.001.330
KEGG	C19141 ;
PubChem CID	6732;
UNII	2KFI1XBH7G ;
CompTox Dashboard (EPA)	DTXSID1025930 ;
	InChI InChI=1S/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3 Key: RZKYEQDPDZUERB-UHFFFAOYSA-N ; InChI=1/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3 Key: RZKYEQDPDZUERB-UHFFFAOYAX;
	SMILES O=C2c1ccccc1C(=O)C2C(=O)C(C)(C)C;
Properties
Chemical formula	C14H14O3
Molar mass	230.26 g/mol
Appearance	Bright-yellow powder[1]
Odor	almost none
Density	1.06 g/mL
Melting point	110 °C (230 °F; 383 K)
Solubility in water	0.002% (25°C)[1]
Hazards
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	280 mg/kg (rat, oral); 75 mg/kg (dog, oral); 150 mg/kg (rabbit, oral)[2]
	NIOSH (US health exposure limits):
PEL (Permissible)	TWA 0.1 mg/m3[1]
REL (Recommended)	TWA 0.1 mg/m3[1]
IDLH (Immediate danger)	100 mg/m3[1]
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Pindone is an anticoagulant drug[3] for agricultural use. It is commonly used as a rodenticide in the management of rat and rabbit populations.

It is pharmacologically analogous to warfarin and inhibits the synthesis of Vitamin K-dependent clotting factors.

References

NIOSH Pocket Guide to Chemical Hazards. "#0516". National Institute for Occupational Safety and Health (NIOSH).
"Pindone". Immediately Dangerous to Life and Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
Robinson MH, Twigg LE, Wheeler SH, Martin GR (March 2005). "Effect of the anticoagulant, pindone, on the breeding performance and survival of merino sheep, Ovis aries". Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 140 (3): 465–73. doi:10.1016/j.cbpc.2004.11.011. PMID 15694595.

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