ZCZ-011

ZCZ-011
Identifiers
	IUPAC name 6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole;
ChemSpider	57871143;
Chemical and physical data
Formula	C21H18N2O2S
Molar mass	362.45 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1ccc2c([nH]c(c3ccccc3)c2C(C[N+]([O-])=O)c4sccc4)c1;
	InChI InChI=1S/C21H18N2O2S/c1-14-9-10-16-18(12-14)22-21(15-6-3-2-4-7-15)20(16)17(13-23(24)25)19-8-5-11-26-19/h2-12,17,22H,13H2,1H3; Key:RJSPNRDBWHHFMH-UHFFFAOYSA-N;

ZCZ-011 is a positive allosteric modulator of the cannabinoid CB₁ receptor.^[1]^[2]

References

↑ Justin L. Poklis; Deborah J. Clay; Bogna M. Ignatowska-Jankowska; Chiara Zanato; Ruth A. Ross; Iain R. Greig; Rehab A. Abdullah; Mohammed A. Mustafa; Aron H. Lichtman; Alphonse Poklis (June 2015). "HPLC–MS-MS Determination of ZCZ-011, A Novel Pharmacological Tool for Investigation of the Cannabinoid Receptor in Mouse Brain Using Clean Screen FASt™ Column Extraction". Journal of Analytical Toxicology. 39 (5): 353–358. doi:10.1093/jat/bkv015. PMC 4542657. PMID 25737338.
↑ Bogna M. Ignatowska-Jankowska; Gemma L. Baillie; Steven Kinsey; Molly Crowe; Sudeshna Ghosh; Robert A. Owens; Imad M. Damaj; Justin Poklis; Jenny L Wiley; Matteo Zanda; Chiara Zanato; Iain R. Greig; Aron H. Lichtman; Ruth A. Ross (December 2015). "A Cannabinoid CB₁ Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects". Neuropsychopharmacology. 40 (13): 2948–2959. doi:10.1038/npp.2015.148. PMC 4864630. PMID 26052038.

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Identifiers

IUPAC name 6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole
ChemSpider	57871143
Chemical and physical data
Formula	C₂₁H₁₈N₂O₂S
Molar mass	362.45 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Cc1ccc2c([nH]c(c3ccccc3)c2C(C[N+]([O-])=O)c4sccc4)c1
InChI InChI=1S/C21H18N2O2S/c1-14-9-10-16-18(12-14)22-21(15-6-3-2-4-7-15)20(16)17(13-23(24)25)19-8-5-11-26-19/h2-12,17,22H,13H2,1H3 Key:RJSPNRDBWHHFMH-UHFFFAOYSA-N