SSH3

SSH3
Identifiers
AliasesSSH3, SSH3L, slingshot protein phosphatase 3
External IDsMGI: 2683546 HomoloGene: 32372 GeneCards: SSH3
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.2Start67,303,448 bp[1]
End67,312,607 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

54961

245857

Ensembl

ENSG00000172830

ENSMUSG00000034616

UniProt

Q8TE77

Q8K330

RefSeq (mRNA)

NM_017857
NM_018276

NM_198113
NM_001356620

RefSeq (protein)

NP_060327

NP_932781
NP_001343549

Location (UCSC)Chr 11: 67.3 – 67.31 MbChr 19: 4.26 – 4.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene.[5][6]

Function

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172830 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034616 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (January 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213.
  6. 1 2 "Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)".

Further reading

  • Kligys K, Claiborne JN, DeBiase PJ, Hopkinson SB, Wu Y, Mizuno K, Jones JC (November 2007). "The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes". The Journal of Biological Chemistry. 282 (44): 32520–8. doi:10.1074/jbc.M707041200. PMC 2754063. PMID 17848544.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
  • Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, Sampath R, Bamburg JR, Bernard O (February 2005). "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". The EMBO Journal. 24 (3): 473–86. doi:10.1038/sj.emboj.7600543. PMC 548651. PMID 15660133.
  • Ohta Y, Kousaka K, Nagata-Ohashi K, Ohashi K, Muramoto A, Shima Y, Niwa R, Uemura T, Mizuno K (October 2003). "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin". Genes to Cells. 8 (10): 811–24. doi:10.1046/j.1365-2443.2003.00678.x. PMID 14531860.
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