PTPRO

PTPRO
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2G59, 2GJT
Identifiers
Aliases	PTPRO, GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O, protein tyrosine phosphatase, receptor type O
External IDs	MGI: 1097152 HomoloGene: 21564 GeneCards: PTPRO
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	15,597,399 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	137,463,233 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• phosphoprotein phosphatase activity; • protein homodimerization activity; • phosphatase activity; • Wnt-protein binding; • protein binding; • protein tyrosine phosphatase activity; • transmembrane receptor protein tyrosine phosphatase activity; • hydrolase activity;
Cellular component	• integral component of membrane; • lateral plasma membrane; • membrane; • growth cone; • plasma membrane; • dendritic spine; • integral component of plasma membrane; • axon; • apical plasma membrane; • neuron projection; • extracellular exosome; • lamellipodium;
Biological process	• negative regulation of cell-substrate adhesion; • negative regulation of neuron projection development; • monocyte chemotaxis; • negative regulation of retinal ganglion cell axon guidance; • regulation of glomerular filtration; • slit diaphragm assembly; • protein dephosphorylation; • glomerulus development; • axon guidance; • cell morphogenesis; • glomerular visceral epithelial cell differentiation; • peptidyl-tyrosine dephosphorylation; • negative regulation of glomerular filtration; • negative regulation of canonical Wnt signaling pathway; • lamellipodium assembly; • dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5800
	19277
	ENSG00000151490
	ENSMUSG00000030223
	Q16827
	E9Q612
NM_002848; NM_030667; NM_030668; NM_030669; NM_030670;
	NM_030671
	NM_001164401; NM_001164402; NM_001164403; NM_011216
NP_002839; NP_109592; NP_109593; NP_109594; NP_109595;
	NP_109596
	NP_001157873; NP_001157874; NP_001157875; NP_035346
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.^[5]^[6]^[7]

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000151490 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030223 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Thomas PE, Wharram BL, Goyal M, Wiggins JE, Holzman LB, Wiggins RC (Sep 1994). "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit". J Biol Chem. 269 (31): 19953–62. PMID 7519601.
↑ Wiggins RC, Wiggins JE, Goyal M, Wharram BL, Thomas PE (Oct 1995). "Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13". Genomics. 27 (1): 174–81. doi:10.1006/geno.1995.1021. PMID 7665166.
1 2 "Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O".

Seimiya H, Sawabe T, Inazawa J, Tsuruo T (1995). "Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents". Oncogene. 10 (9): 1731–8. PMID 7753550.
Feito MJ, Bragardo M, Buonfiglio D, et al. (1997). "gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules". Int. Immunol. 9 (8): 1141–7. doi:10.1093/intimm/9.8.1141. PMID 9263011.
Avraham S, London R, Tulloch GA, et al. (1998). "Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells". Gene. 204 (1–2): 5–16. doi:10.1016/S0378-1119(97)00420-4. PMID 9434160.
Taniguchi Y, London R, Schinkmann K, et al. (1999). "The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor". Blood. 94 (2): 539–49. PMID 10397721.
Aguiar RC, Yakushijin Y, Kharbanda S, et al. (1999). "PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest". Blood. 94 (7): 2403–13. PMID 10498613.
Wang Z, Bhattacharya N, Meyer MK, et al. (2001). "Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells". Arch. Biochem. Biophys. 390 (1): 9–18. doi:10.1006/abbi.2001.2370. PMID 11368509.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Motiwala T, Kutay H, Ghoshal K, et al. (2004). "Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13844–9. doi:10.1073/pnas.0405451101. PMC 518843. PMID 15356345.
Chen L, Juszczynski P, Takeyama K, et al. (2007). "Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation". Blood. 108 (10): 3428–33. doi:10.1182/blood-2006-03-013821. PMID 16888096.
Motiwala T, Majumder S, Kutay H, et al. (2007). "Methylation and Silencing of Protein Tyrosine Phosphatase Receptor Type O in Chronic Lymphocytic Leukemia". Clin. Cancer Res. 13 (11): 3174–81. doi:10.1158/1078-0432.CCR-06-1720. PMC 3074612. PMID 17545520.
Tian J, Wang HP, Mao YY, et al. (2007). "Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy". J. Int. Med. Res. 35 (3): 338–45. doi:10.1177/147323000703500308. PMID 17593862.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000151490 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030223 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid7519601-5] Thomas PE, Wharram BL, Goyal M, Wiggins JE, Holzman LB, Wiggins RC (Sep 1994). "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit". J Biol Chem. 269 (31): 19953–62. PMID 7519601.

[pmid7665166-6] Wiggins RC, Wiggins JE, Goyal M, Wharram BL, Thomas PE (Oct 1995). "Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13". Genomics. 27 (1): 174–81. doi:10.1006/geno.1995.1021. PMID 7665166.

[entrez-7] 1 2 "Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O".

PTPRO

References

Further reading