Ro 04-6790

Ro 04-6790
Clinical data
ATC code	none;
Identifiers
	IUPAC name 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide;
CAS Number	202466-68-0;
PubChem CID	5312145;
IUPHAR/BPS	274;
ChemSpider	4471575;
ChEMBL	CHEMBL433461;
Chemical and physical data
Formula	C12H16N6O2S
Molar mass	308.359 g/mol
3D model (JSmol)	Interactive image;
	SMILES Nc2ccc(cc2)S(=O)(=O)Nc1cc(NC)nc(NC)n1;
	InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18); Key:JELFWSXQTXRMAJ-UHFFFAOYSA-N;
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Ro 04-6790 is a drug, developed by Hoffmann–La Roche, which has applications in scientific research. It acts as a potent and selective receptor antagonist for the 5-HT₆ serotonin receptor subtype, with little or no affinity at other receptors. In common with other drugs of this class,^[1] Ro 04-6790 has nootropic effects in animals,^[2] and reduces the amnesia produced by memory-impairing drugs such as dizocilpine^[3] and scopolamine.^[4]

References

↑ Fone KC. An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology. 2008 Nov;55(6):1015-22. doi:10.1016/j.neuropharm.2008.06.061 PMID 18655798
↑ King MV, Spicer CH, Sleight AJ, Marsden CA, Fone KC. Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task. Psychopharmacology. 2008 Oct 7. PMID 18839151
↑ Pitsikas N, Zisopoulou S, Pappas I, Sakellaridis N. The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801. Behavioural Brain Research. 2008 Apr 9;188(2):304-9. PMID 18164078
↑ Woolley ML, Marsden CA, Sleight AJ, Fone KC. Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. Psychopharmacology. 2003 Dec;170(4):358-67. PMID 13680084

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Psychoanaleptics: Anti-dementia agents (ATC code N06D and others)
AChE inhibitor medications	Donepezil Galantamine Ipidacrine Rivastigmine Tacrine
Other medications	Bifemelane Ginkgo folium Meclofenoxate (centrophenoxine) Memantine Nicergoline
Experimental BACE inhibitors	Lanabecestat Verubecestat

Clinical data

ATC code	none
Identifiers
IUPAC name 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide
CAS Number	202466-68-0
PubChem CID	5312145
IUPHAR/BPS	274
ChemSpider	4471575
ChEMBL	CHEMBL433461
Chemical and physical data
Formula	C₁₂H₁₆N₆O₂S
Molar mass	308.359 g/mol
3D model (JSmol)	Interactive image
SMILES Nc2ccc(cc2)S(=O)(=O)Nc1cc(NC)nc(NC)n1
InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) Key:JELFWSXQTXRMAJ-UHFFFAOYSA-N
(verify)