RS-56812

RS-56812
Identifiers
	IUPAC name N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide;
CAS Number	143137-35-3;
PubChem CID	6604789;
Chemical and physical data
Formula	C18H21N3O2
Molar mass	311.377 g/mol
3D model (JSmol)	Interactive image;
	SMILES c14ccccc4n(C)cc1C(=O)C(=O)NC2CN3CCC2CC3;
(verify)

RS-56812 is a potent and selective partial agonist at the 5HT₃ receptor.^[1] It has been shown to improve performance on animal tests of memory.^[2]

References

↑ Van Hooft JA, Vijverberg HP. RS-056812-198: partial agonist on native and antagonist on cloned 5-HT3 receptors. European Journal of Pharmacology. 1997 Mar 19;322(2-3):229-33. PMID 9098692
↑ Terry AV Jr, Buccafusco JJ, Prendergast MA, Jackson WJ, Fontana DL, Wong EH, Whiting RL, Eglen RM. The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys. Neuroreport. 1996 Dec 20;8(1):49-54. PMID 9051751

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[1] Van Hooft JA, Vijverberg HP. RS-056812-198: partial agonist on native and antagonist on cloned 5-HT3 receptors. European Journal of Pharmacology. 1997 Mar 19;322(2-3):229-33. PMID 9098692

[2] Terry AV Jr, Buccafusco JJ, Prendergast MA, Jackson WJ, Fontana DL, Wong EH, Whiting RL, Eglen RM. The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys. Neuroreport. 1996 Dec 20;8(1):49-54. PMID 9051751

Identifiers

IUPAC name N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide
CAS Number	143137-35-3
PubChem CID	6604789
Chemical and physical data
Formula	C₁₈H₂₁N₃O₂
Molar mass	311.377 g/mol
3D model (JSmol)	Interactive image
SMILES c14ccccc4n(C)cc1C(=O)C(=O)NC2CN3CCC2CC3
(verify)