Oncostatin M receptor

OSMR
Identifiers
Aliases	OSMR, OSMRB, PLCA1, IL-31R-beta, IL-31RB, oncostatin M receptor
External IDs	OMIM: 601743 MGI: 1330819 HomoloGene: 2972 GeneCards: OSMR
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	38,945,596 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	6,874,969 bp[2]
Gene ontology
Molecular function	• cytokine receptor activity; • oncostatin-M receptor activity; • growth factor binding; • cytokine binding;
Cellular component	• integral component of membrane; • oncostatin-M receptor complex; • plasma membrane; • apical plasma membrane; • membrane; • external side of plasma membrane; • receptor complex;
Biological process	• positive regulation of acute inflammatory response; • response to cytokine; • oncostatin-M-mediated signaling pathway; • positive regulation of cell proliferation; • cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9180
	18414
	ENSG00000145623
	ENSMUSG00000022146
	Q99650
	O70458
NM_001168355; NM_003999; NM_001323504; NM_001323505; NM_001323506;
	NM_001323507
	NM_011019; NM_001310469
NP_001161827; NP_001310433; NP_001310434; NP_001310435; NP_001310436;
	NP_003990
	NP_001297398; NP_035149
	Wikidata
View/Edit Human	View/Edit Mouse

Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor, is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene.^[5]^[6]

OSMR is a member of the type I cytokine receptor family. This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events.^[5]

Clinical significance

The oncostatin M receptor is associated with primary cutaneous amyloidosis.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000145623 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022146 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: oncostatin M receptor".
↑ Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D (December 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. 271 (51): 32635–43. doi:10.1074/jbc.271.51.32635. PMID 8999038.
↑ Arita K, South AP, Hans-Filho G, et al. (January 2008). "Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis". Am. J. Hum. Genet. 82 (1): 73–80. doi:10.1016/j.ajhg.2007.09.002. PMC 2253984. PMID 18179886.

External links

Oncostatin+M+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000145623 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022146 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] 1 2 "Entrez Gene: oncostatin M receptor".

[pmid8999038-6] Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D (December 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. 271 (51): 32635–43. doi:10.1074/jbc.271.51.32635. PMID 8999038.

[pmid18179886-7] Arita K, South AP, Hans-Filho G, et al. (January 2008). "Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis". Am. J. Hum. Genet. 82 (1): 73–80. doi:10.1016/j.ajhg.2007.09.002. PMC 2253984. PMID 18179886.