CCRL2

CCRL2
Identifiers
AliasesCCRL2, ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR, C-C motif chemokine receptor like 2
External IDsMGI: 1920904 HomoloGene: 2948 GeneCards: CCRL2
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p21.31Start46,407,163 bp[1]
End46,412,997 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

9034

54199

Ensembl

ENSG00000121797

ENSMUSG00000043953

UniProt

O00421

O35457

RefSeq (mRNA)

NM_001130910
NM_003965

NM_017466
NM_001302376
NM_001302377

RefSeq (protein)

NP_001124382
NP_003956

NP_001289305
NP_001289306
NP_059494

Location (UCSC)Chr 3: 46.41 – 46.41 MbChr 9: 111.05 – 111.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-C chemokine receptor-like 2 is a protein that in humans is encoded by the CCRL2 gene.[5][6] Recently it was found that CCRL2 also acts as a receptor for the chemokine chemerin.[7]

Function

This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000121797 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043953 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Fan P, Kyaw H, Su K, Zeng Z, Augustus M, Carter KC, Li Y (Mar 1998). "Cloning and characterization of a novel human chemokine receptor". Biochem Biophys Res Commun. 243 (1): 264–8. doi:10.1006/bbrc.1997.7981. PMID 9473515.
  6. 1 2 "Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2".
  7. ↑ Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC (September 2008). "Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis". J. Exp. Med. 205 (10): 2207–20. doi:10.1084/jem.20080300. PMC 2556791. PMID 18794339.

Further reading

  • Daugherty BL, Springer MS (1997). "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21". Genomics. 41 (2): 294–5. doi:10.1006/geno.1997.4626. PMID 9143512.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Galligan CL, Matsuyama W, Matsukawa A, et al. (2004). "Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis". Arthritis Rheum. 50 (6): 1806–14. doi:10.1002/art.20275. PMID 15188357.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.