Isopropamide

Isopropamide

Clinical data
MedlinePlus	a694006
Routes of administration	Oral
ATC code	A03AB09 (WHO)
Legal status
Legal status	US: ℞-only and Unscheduled In general: unscheduled
Identifiers
IUPAC name 4-amino-N,N-diisopropyl-N-methyl-4-oxo-3,3-diphenylbutan-1-aminium
CAS Number	7492-32-2 N
PubChem CID	3775
DrugBank	DB01625 Y
ChemSpider	3643 Y
UNII	8B9I31H724
ChEMBL	CHEMBL1201232 N
ECHA InfoCard	100.028.470
Chemical and physical data
Formula	C23H33N2O+
Molar mass	353.52092 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(N)C(c1ccccc1)(c2ccccc2)CC[N+](C(C)C)(C(C)C)C
InChI InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1 Y Key:JTPUMZTWMWIVPA-UHFFFAOYSA-O Y
NY (what is this?)  (verify)

Isopropamide (R5) is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt. It was discovered at Janssen Pharmaceutica in 1954.

References

• Seeherman R, Isopropamide iodide: a long-acting anticholinergic, Del Med J. 1957 Oct;29(10):265-9.
• Boss EG Jr, Buchanan GC, Effect of isopropamide iodide on basal gastric secretion in the human, Gastroenterology. 1957 Nov;33(5):730-6.