GFRA3

GFRA3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGFRA3, GDNFR3, GDNF family receptor alpha 3
External IDsMGI: 1201403 HomoloGene: 1146 GeneCards: GFRA3
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q31.2Start138,252,379 bp[1]
End138,274,671 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2676

14587

Ensembl

ENSG00000146013

ENSMUSG00000024366

UniProt

O60609

O35118

RefSeq (mRNA)

NM_001496

NM_010280

RefSeq (protein)

NP_001487

NP_034410

Location (UCSC)Chr 5: 138.25 – 138.27 MbChr 18: 34.69 – 34.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene.[5][6]

Function

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.[6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000146013 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024366 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (Dec 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry. 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. PMID 9407096.
  6. 1 2 "Entrez Gene: GFRA3 GDNF family receptor alpha 3".

Further reading

  • Wang X, Baloh RH, Milbrandt J, Garcia KC (Jun 2006). "Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors". Structure. 14 (6): 1083–92. doi:10.1016/j.str.2006.05.010. PMID 16765900.
  • Zhang Z, Henzel WJ (Oct 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. Check date values in: |year= / |date= mismatch (help)
  • Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM, Eng C (Apr 2001). "Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma". Oncogene. 20 (17): 2161–70. doi:10.1038/sj.onc.1204289. PMID 11360200.
  • Onochie CI, Korngut LM, Vanhorne JB, Myers SM, Michaud D, Mulligan LM (Sep 2000). "Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease". Journal of Medical Genetics. 37 (9): 674–9. doi:10.1136/jmg.37.9.674. PMC 1734691. PMID 10978357.
  • Baloh RH, Tansey MG, Lampe PA, Fahrner TJ, Enomoto H, Simburger KS, Leitner ML, Araki T, Johnson EM, Milbrandt J (Dec 1998). "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex". Neuron. 21 (6): 1291–302. doi:10.1016/S0896-6273(00)80649-2. PMID 9883723. Check date values in: |year= / |date= mismatch (help)
  • Baloh RH, Gorodinsky A, Golden JP, Tansey MG, Keck CL, Popescu NC, Johnson EM, Milbrandt J (May 1998). "GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family". Proceedings of the National Academy of Sciences of the United States of America. 95 (10): 5801–6. doi:10.1073/pnas.95.10.5801. PMC 20460. PMID 9576965.
  • Masure S, Cik M, Pangalos MN, Bonaventure P, Verhasselt P, Lesage AS, Leysen JE, Gordon RD (Feb 1998). "Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3)". European Journal of Biochemistry / FEBS. 251 (3): 622–30. doi:10.1046/j.1432-1327.1998.2510622.x. PMID 9490034.
  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (Sep 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101. Check date values in: |year= / |date= mismatch (help)


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