Cytosol alanyl aminopeptidase

Cytosol alanyl aminopeptidase
Identifiers
EC number 3.4.11.14
CAS number 243859-94-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Cytosol alanyl aminopeptidase (EC 3.4.11.14, arylamidase, aminopolypeptidase, thiol-activated aminopeptidase, human liver aminopeptidase, puromycin-sensitive aminopeptidase, soluble alanyl aminopeptidase, cytosol aminopeptidase III, alanine aminopeptidase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides

This puromycin-sensitive enzyme is Co2+-activated zinc-sialoglycoprotein.

References

  1. ↑ Starnes WL, Behal FJ (July 1974). "A human liver aminopeptidase. The amino acid and carbohydrate content, and some physical properties of a sialic acid containing glycoprotein". Biochemistry. 13 (16): 3221–7. doi:10.1021/bi00713a004. PMID 4841062.
  2. ↑ Kao YJ, Starnes WL, Behal FJ (July 1978). "Human kidney alanine aminopeptidase: physical and kinetic properties of a sialic acid containing glycoprotein". Biochemistry. 17 (15): 2990–4. doi:10.1021/bi00608a008. PMID 698181.
  3. ↑ Sidorowicz W, Hsia WC, Maslej-Zownir O, Behal FJ (November 1980). "Multiple molecular forms of human alanine aminopeptidase: immunochemical properties". Clinica Chimica Acta; International Journal of Clinical Chemistry. 107 (3): 245–56. doi:10.1016/0009-8981(80)90452-0. PMID 6108169.
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