Alpha-3 beta-2 nicotinic receptor

The alpha-3 beta-2 nicotinic receptor, also known as the α3β2 receptor, is a type of nicotinic acetylcholine receptor, consisting of α3 and β2 subunits.

It occurs alongside the more common α3β4 nicotinic receptor in autonomic ganglia, and as a faciliatory presynaptic autoreceptor at the neuromuscular junction (NMJ). At the NMJ, it is involved in upregulation of ACh release during high-frequency stimulation. Blockage of this receptor in the presence of a partial postsynaptic neuromuscular block is thought to produce the characteristic tetanic fade caused by non-depolarizing neuromuscular blockers.[1]

Ligands

Agonists

PAMs

Antagonists

See also

References

  1. ↑ https://academic.oup.com/bja/article/103/1/108/463216; retrieved 10-09-2018
  2. 1 2 3 4 5 6 7 8 9 Chavez-Noriega LE, Gillespie A, Stauderman KA, et al. (October 2000). "Characterization of the recombinant human neuronal nicotinic acetylcholine receptors alpha3beta2 and alpha4beta2 stably expressed in HEK293 cells". Neuropharmacology. 39 (13): 2543–60. doi:10.1016/s0028-3908(00)00134-9. PMID 11044726.
  3. ↑ Mihalak KB, Carroll FI, Luetje CW (September 2006). "Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors". Mol. Pharmacol. 70 (3): 801–5. doi:10.1124/mol.106.025130. PMID 16766716.
  4. ↑ Levandoski MM, Piket B, Chang J (June 2003). "The anthelmintic levamisole is an allosteric modulator of human neuronal nicotinic acetylcholine receptors". Eur. J. Pharmacol. 471 (1): 9–20. doi:10.1016/s0014-2999(03)01796-5. PMID 12809947.
  5. ↑ Seo S, Henry JT, Lewis AH, Wang N, Levandoski MM (July 2009). "The positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptors". J. Neurosci. 29 (27): 8734–42. doi:10.1523/JNEUROSCI.1859-09.2009. PMC 2726771. PMID 19587280.
  6. ↑ Crooks PA, Bardo MT, Dwoskin LP (2014). "Nicotinic receptor antagonists as treatments for nicotine abuse". Adv. Pharmacol. 69: 513–51. doi:10.1016/B978-0-12-420118-7.00013-5. PMC 4110698. PMID 24484986.
  7. ↑ Lee RH, Tseng TY, Wu CY, et al. (2012). "Memantine inhibits α3β2-nAChRs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries". PLoS ONE. 7 (7): e40326. doi:10.1371/journal.pone.0040326. PMC 3390354. PMID 22792283.


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