GRID1

GRID1
Identifiers
AliasesGRID1, GluD1, glutamate ionotropic receptor delta type subunit 1
External IDsMGI: 95812 HomoloGene: 69017 GeneCards: GRID1
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q23.1-q23.2Start85,599,555 bp[1]
End86,366,493 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2894

14803

Ensembl

ENSG00000182771

ENSMUSG00000041078

UniProt

Q9ULK0

Q61627

RefSeq (mRNA)

NM_017551

NM_008166

RefSeq (protein)

NP_060021

NP_032192

Location (UCSC)Chr 10: 85.6 – 86.37 MbChr 14: 34.82 – 35.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a protein[5][6] that in humans is encoded by the GRID1 gene.[7][8]

Function

This gene encodes a subunit of glutamate receptor ligand-gated ion channel. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[7]

Clinical significance

Several genetic epidemiology studies have shown a strong association between several variants of the GRID1 gene and increased risk of developing schizophrenia.[9][10]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182771 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041078 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Yamazaki M, Araki K, Shibata A, Mishina M (March 1992). "Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family". Biochem. Biophys. Res. Commun. 183 (2): 886–92. doi:10.1016/0006-291X(92)90566-4. PMID 1372507.
  6. ↑ Treadaway J, Zuo J (December 1998). "Mapping of the mouse glutamate receptor delta1 subunit (Grid1) to chromosome 14". Genomics. 54 (2): 359–60. doi:10.1006/geno.1998.5599. PMID 9828146.
  7. 1 2 "Entrez Gene: GRID1 glutamate receptor, ionotropic, delta 1".
  8. ↑ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
  9. ↑ Guo SZ, Huang K, Shi YY, Tang W, Zhou J, Feng GY, Zhu SM, Liu HJ, Chen Y, Sun XD, He L (July 2007). "A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population". Schizophr. Res. 93 (1–3): 385–90. doi:10.1016/j.schres.2007.03.007. PMID 17490860.
  10. ↑ Treutlein J, Mühleisen TW, Frank J, Mattheisen M, Herms S, Ludwig KU, Treutlein T, Schmael C, Strohmaier J, Bösshenz KV, Breuer R, Paul T, Witt SH, Schulze TG, Schlösser RG, Nenadic I, Sauer H, Becker T, Maier W, Cichon S, Nöthen MM, Rietschel M (June 2009). "Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter". Schizophr. Res. 111 (1–3): 123–30. doi:10.1016/j.schres.2009.03.011. PMID 19346103.

Further reading

  • Fallin MD, Lasseter VK, Avramopoulos D, et al. (2006). "Bipolar I Disorder and Schizophrenia: A 440–Single-Nucleotide Polymorphism Screen of 64 Candidate Genes among Ashkenazi Jewish Case-Parent Trios". Am. J. Hum. Genet. 77 (6): 918–36. doi:10.1086/497703. PMC 1285177. PMID 16380905.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yue Z, Horton A, Bravin M, et al. (2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9. PMID 12372286.
  • Ly CD, Roche KW, Lee HK, Wenthold RJ (2002). "Identification of rat EMAP, a delta-glutamate receptor binding protein". Biochem. Biophys. Res. Commun. 291 (1): 85–90. doi:10.1006/bbrc.2002.6413. PMID 11829466.
  • Roche KW, Ly CD, Petralia RS, et al. (1999). "Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses". J. Neurosci. 19 (10): 3926–34. PMID 10234023.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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