SKF-91488

SKF-91488
Names
	IUPAC name 4-(Dimethylamino)butyl carbamimidothioate
Identifiers
CAS Number	68643-23-2;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1230270;
ChemSpider	5037;
DrugBank	DB07106;
PubChem CID	5227;
UNII	1I4LVX494H;
CompTox Dashboard (EPA)	DTXSID50988329 ;
	InChI InChI=1S/C7H17N3S/c1-10(2)5-3-4-6-11-7(8)9/h3-6H2,1-2H3,(H3,8,9) Key: UFYJLJINUGVUHO-UHFFFAOYSA-N;
	SMILES [H]/N=C(/N)\SCCCCN(C)C;
Properties
Chemical formula	C7H17N3S
Molar mass	175.29 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

SKF-91488 is a histamine N-methyltransferase inhibitor. It prevents the degradation of histamine, leading to increased histamine levels.[1][2]

References

Thakkar, Mahesh M. (February 2011). "Histamine in the regulation of wakefulness". Sleep Medicine Reviews. 15 (1): 65–74. doi:10.1016/j.smrv.2010.06.004. PMC 3016451. PMID 20851648.
Tamaoki, J.; Chiyotani, A.; Tagaya, E.; Isono, K.; Konno, K. (1994). "Histamine N-methyltransferase Modulates Human Bronchial Smooth Muscle Contraction". Mediators of Inflammation. 3 (2): 125–129. doi:10.1155/S0962935194000153. PMC 2367027. PMID 18472930.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.