alpha-Fluoromethylhistidine
α-Fluoromethylhistidine (α-FMH) is an irreversible histidine decarboxylase inhibitor.[1] It has potent sleep-inducing effects.[2][3][4]
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α-FMH | |
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| C7H10FN3O2 | |
| Molar mass | 187.174 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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References
- August, Thomas F; Musson, Donald G; Hwang, Stephen S; Duggan, Daniel E; Hooke, Kay F; Roman, Izabela J; Ferguson, Robert J; Bayne, W.F (1985). "Bioanalysis and disposition of α-fluoromethylhistidine, a new histidine decarboxylase inhibitor". Journal of Pharmaceutical Sciences. 74 (8): 871–5. doi:10.1002/jps.2600740814. PMID 4032273.
- Thakkar, M. M (2011). "HISTAMINE IN THE REGULATION OF WAKEFULNESS". Sleep Medicine Reviews. 15 (1): 65–74. doi:10.1016/j.smrv.2010.06.004. PMC 3016451. PMID 20851648.
- Monti, J. M; d'Angelo, Luisa; Jantos, H; Pazos, Sheila (1988). "Effects of a-fluoromethylhistidine on sleep and wakefulness in the rat". Journal of Neural Transmission. 72 (2): 141–5. doi:10.1007/bf01250237. PMID 3385425.
- Oishi, Ryozo; Itoh, Yoshinori; Nishibori, Masahiro; Saeki, Kiyomi; Ueki, Showa (1988). "Enhancement by α-fluoromethylhistidine of the thiopental sleep-prolonging action of Δ9-tetrahydrocannabinol". Psychopharmacology. 95. doi:10.1007/bf00212771.
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