Haplogroup I (mtDNA)

The highest frequencies of mitochondrial haplogroup I observed so far appear in the Cushitic-speaking El Molo (23%) and Rendille (>17%) in northern Kenya (Castrì 2008). The clade is also found at comparable frequencies among the Soqotri (~22%).[1]

Haplogroup I is present across West Asia and Central Asia, and is also found at trace frequencies in South Asia. Its highest frequency area is perhaps in northern Iran (9.7%). Terreros 2011 notes that it also has high diversity there and reiterates past studies that have suggested that this may be its place of origin. Found in Svan population from Georgia(Caucasus) I* 4.2%."Sequence polymorphisms of the mtDNA control region in a human isolate: the Georgians from Swanetia."Alfonso-Sánchez MA1, Martínez-Bouzas C, Castro A, Peña JA, Fernández-Fernández I, Herrera RJ, de Pancorbo MM. The table below shows some of the populations where it has been detected.

In Western Europe, haplogroup I is most common in Northwestern Europe (Norway, the Isle of Skye, and the British Isles). The frequency in these areas is between 2 and 5 percent. Its highest frequency in Brittany, France where it is over 9 percent of the population in Finistère. It is uncommon and sometimes absent in other parts of Western Europe (Iberia, South-West France, and parts of Italy).

In Eastern Europe, the frequency of haplogroup I is generally lower than in Western Europe (1 to 3 percent), but its frequency is more consistent between populations with fewer places of extreme highs or lows. There are two notable exceptions. Nikitin 2009 found that Lemkos (a sub- or co-ethnic group of Rusyns) in the Carpathian mountains have the "highest frequency of haplogroup I (11.3%) in Europe, identical to that of the population of Krk Island (Croatia) in the Adriatic Sea".[Footnote 1][Footnote 2]

Haplogroup I has until recently been absent from ancient European samples found in Paleolithic and Mesolithic grave sites. In 2017, in a site on Italian island of Sardinia was found a sample with the subclade I3 dated to 9124-7851 BC (Modi 2017), while in the Near East, in Levant was found a sample with yet-not-defined subclade dated 8,850-8,750 BC, while in Iran was found a younger sample with subclade I1c dated to 3972-3800 BC (Lazaridis 2016). In Neolithic Spain (c. 6090-5960 BC in Paternanbidea, Navarre) was found a sample with yet-not-defined subclade (Olivieri 2013). Haplogroup I displays a strong connection with the Indo-European migrations; especially its I1, I1a1 and I3a subclades, which have been found in Poltavka and Srubnaya cultures in Russia (Mathieson 2015), among ancient Scythians (Der Sarkissian 2011), and in Corded Ware and Unetice Culture burials in Saxony (Brandt 2013). Haplogroup I (with undetermined subclades) has also been noted at significant frequencies in more recent historic grave sites (Melchior 2008 and Hofreiter 2010).

In 2013, Nature announced the publication of the first genetic study utilizing next-generation sequencing to ascertain the ancestral lineage of an Ancient Egyptian individual. The research was led by Carsten Pusch of the University of Tübingen in Germany and Rabab Khairat, who released their findings in the Journal of Applied Genetics. DNA was extracted from the heads of five Egyptian mummies that were housed at the institution. All the specimens were dated to between 806 BC and 124 AD, a time frame corresponding with the Late Dynastic and Ptolemaic periods. The researchers observed that one of the mummified individuals likely belonged to the I2 subclade.[2] Haplogroup I has also been found among ancient Egyptian mummies excavated at the Abusir el-Meleq archaeological site in Middle Egypt, which date from the Pre-Ptolemaic/late New Kingdom, Ptolemaic, and Roman periods.[3]

Haplogroup I5 has also been observed among specimens at the mainland cemetery in Kulubnarti, Sudan, which date from the Early Christian period (AD 550-800).[4]

The frequency of haplogroup I may have undergone a reduction in Europe following the Middle Ages. An overall frequency of 13% was found in ancient Danish samples from the Iron Age to the Medieval Age (including Vikings) from Denmark and Scandinavia compared to only 2.5% in modern samples. As haplogroup I is not observed in any ancient Italian, Spanish [contradicted by the recent research as have been found in pre-Neolithic Italy as well Neolithic Spain], British, central European populations, early central European farmers and Neolithic samples, according to the authors "Haplogroup I could, therefore, have been an ancient Southern Scandinavian type "diluted" by later immigration events" (Hofreiter 2010).

This phylogenetic tree of haplogroup I subclades with time estimates is based on the paper and published research (Olivieri 2013).

It formed during the Last Glacial pre-warming period. It is found mainly in Europe, Near East, occasionally in North Africa and the Caucasus. It is the most frequent clade of the haplogroup (Olivieri 2013).

The subclade frequency peaks (circa 2.8%) are mostly located in North-Eastern Europe (Olivieri 2013).

It is the common root clade for subclades I2 and I3. There's a sample from Tanzania with which I2'3 shares a variant at position 152 from the root node of haplogroup I, and this "node 152" could be upstream I2'3s clade (Olivieri 2013). Both I2 and I3 might have formed during the Holocene period, and most of their subclades are from Europe, only few from the Near East (Olivieri 2013). Examples of this ancestral branch have not been documented.

The clade splits into subclades I4a and newly defined I4b, with samples found in Europe, the Near East and the Caucasus (Olivieri 2013).

Is the second most frequent clade of the haplogroup. Its subclades are found in Europe, e.g. I5a1, and the Near East, e.g. I5a2a and I5b (Olivieri 2013).

The subclade is very rare, found until July 2013 only in four samples from the Near East (Olivieri 2013).

It is the rarest defined subclade, until July 2013 found only in two samples from the Near East and the Caucasus (Olivieri 2013).

• Behar; Family Tree DNA (2012). "mtDNA Community".

• Černý, Viktor; Pereira, Luísa; Kujanová, Martina; VašÍková, Alžběta; Hájek, Martin; Morris, Miranda; Mulligan, Connie J. (2009). "Out of Arabia-The settlement of Island Soqotra as revealed by mitochondrial and Y chromosome genetic diversity". American Journal of Physical Anthropology. 138 (4): 439–47. doi:10.1002/ajpa.20960. PMID 19012329.
• Fellner, Robert O (1995). Cultural change and the epipalaeolithic of Palestine. Tempus Reparatum. ISBN 9780860547754.
• Kitchen, A.; Ehret, C.; Assefa, S.; Mulligan, C. J. (2009). "Bayesian phylogenetic analysis of Semitic languages identifies an Early Bronze Age origin of Semitic in the Near East". Proceedings of the Royal Society B: Biological Sciences. 276 (1668): 2703–10. doi:10.1098/rspb.2009.0408. PMC 2839953. PMID 19403539.
• Petit-Maire, Nicole; Bouysse, Philippe (2000). "Geological records of the recent past, a key to the near future world environments" (PDF). Episodes. 23 (4): 230–246. doi:10.18814/epiiugs/2000/v23i4/001.