Zn2+-exporting ATPase

zinc-exporting ATPase
Identifiers
EC number 3.6.3.5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a Zn2+-exporting ATPase (EC 3.6.3.5) is an enzyme that catalyzes the chemical reaction

ATP + H2O + Zn2+in ADP + phosphate + Zn2+out

The 3 substrates of this enzyme are ATP, H2O, and Zn2+, whereas its 3 products are ADP, phosphate, and Zn2+.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (Zn2+-exporting). Other names in common use include Zn(II)-translocating P-type ATPase, P1B-type ATPase, and AtHMA4 (the A. thaliana protein).

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1MWY and 1MWZ.

References

    • Beard SJ, Hashim R, Membrillo-Hernandez J, Hughes MN, Poole RK (1997). "Zinc(II) tolerance in Escherichia coli K-12: evidence that the zntA gene (o732) encodes a cation transport ATPase". Mol. Microbiol. 25 (5): 883&ndash, 91. doi:10.1111/j.1365-2958.1997.mmi518.x. PMID 9364914.
    • Rensing C, Mitra B, Rosen BP (1997). "The zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14326&ndash, 31. doi:10.1073/pnas.94.26.14326. PMC 24962. PMID 9405611.
    • Rensing C, Sun Y, Mitra B, Rosen BP (1998). "Pb(II)-translocating P-type ATPases". J. Biol. Chem. 273 (49): 32614&ndash, 7. doi:10.1074/jbc.273.49.32614. PMID 9830000.
    • Krijger GC, Williams LE (2005). "The plant P1B-type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels". FEBS Lett. 579 (3): 783&ndash, 91. doi:10.1016/j.febslet.2004.12.040. PMID 15670847.
    • Eren E, Arguello JM (2004). "Arabidopsis HMA2, a Divalent Heavy Metal-Transporting PIB-Type ATPase, Is Involved in Cytoplasmic Zn2+ Homeostasis". Plant Physiol. 136 (3): 3712&ndash, 23. doi:10.1104/pp.104.046292. PMC 527169. PMID 15475410.


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