Tuberculosinol synthase

Tuberculosinol synthase
Crystal structure of tuberculosinol synthase. PDB entry 4cmv[1]
Identifiers
EC number 3.1.7.8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Tuberculosinol synthase (EC 3.1.7.8, Rv3378c) is an enzyme with systematic name tuberculosinyl diphosphate diphosphohydrolase (tuberculosinol forming).[2][3] This enzyme catalyses the following chemical reaction

tuberculosinyl diphosphate + H2O [tuberculosinol] + diphosphate

This enzyme is present in Mycobacterium that cause tuberculosis.

References

  1. ↑ Layre E, Lee HJ, Young DC, Martinot AJ, Buter J, Minnaard AJ, Annand JW, Fortune SM, Snider BB, Matsunaga I, Rubin EJ, Alber T, Moody DB (February 2014). "Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c". Proceedings of the National Academy of Sciences of the United States of America. 111 (8): 2978–83. doi:10.1073/pnas.1315883111. PMC 3939896. PMID 24516143.
  2. ↑ Nakano C, Ootsuka T, Takayama K, Mitsui T, Sato T, Hoshino T (2011). "Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome". Bioscience, Biotechnology, and Biochemistry. 75 (1): 75–81. doi:10.1271/bbb.100570. PMID 21228491.
  3. ↑ Hoshino T, Nakano C, Ootsuka T, Shinohara Y, Hara T (April 2011). "Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis". Organic & Biomolecular Chemistry. 9 (7): 2156–65. doi:10.1039/c0ob00884b. PMID 21290071.
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