Thioesterase

Thioesterases are enzymes which belong to the esterase family. Esterases, in turn, are one type of the several hydrolases known.

Thioesterases exhibit Esterase activity (splitting of an ester into acid and alcohol, in the presence of water) specifically at a thiol group.

Thioesterases or thiolester hydrolases are identified as members of E.C.3.1.2.

Examples

Acetyl-CoA hydrolase, palmitoyl-CoA hydrolase, succinyl-CoA hydrolase, formyl-CoA hydrolase, acyl-CoA hydrolase are a few examples of this group of enzymes.

Ubiquitin thiolesterase is a well-known example, whose structure has been analyzed.

Humans genes which encode thioesterases include:[1]

ACOT1, ACOT2, ACOT4, ACOT6, ACOT7, ACOT8, ACOT9, ACOT11 (STARD14), ACOT12 (STARD15), OLAH, PPT1, PPT2, THEM2 (ACOT13), THEM4, THEM4P1, THEM5

References

  1. ↑ Brocker, C; Carpenter, C; Nebert, DW; Vasiliou, V (Aug 2010). "Evolutionary divergence and functions of the human acyl-CoA thioesterase gene ( ACOT ) family". Human Genomics. 4 (6): 411–20. PMC 3525216. PMID 20846931.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.