Pseudoviridae

Pseudoviridae
Virus classification
Group: Group VI (ssRNA-RT)
Order: Ortervirales
Family: Pseudoviridae
Genera

Hemivirus
Pseudovirus
Sirevirus

The Pseudoviridae are a family of viruses, including the following genera:

  • Genus Pseudovirus; type species: Saccharomyces cerevisiae Ty1 virus
  • Genus Hemivirus; type species: Drosophila melanogaster copia virus

The type species Saccharomyces cerevisiae Ty1 virus, from the genus pseudovirus and the type species Drosophila melanogaster copia virus from the genus Hemivirus, both belong to the Pseudoviridae family.

Taxonomy

Pseudoviridae is unofficially classified under group VI RNA Reverse Transcribing Viruses and infect fungi and invertebrates.

Pseudoviridae comprises highly divergent members and most Pseudoviridae encode Gag and Pol on a single open reading frame.

Pseudoviridae is included in the order Ortervirales along with families Belpaoviridae, Metaviridae, Retroviridae, and Caulimoviridae.[1]

Genome

The genome of viruses from this family is unsegmented, -RT, positive-sense, single-stranded RNA and is 4200–9700 nucleotides long. The genome encodes structural proteins and non-structural proteins which codes for an RNA-dependent DNA polymerase, replicase, and reverse transcriptase for the reverse transcription step during replication.

Virology

The viral capsid is unenveloped and looks roughly spherical. The capsid is round with icosahedral symmetry with triangulation number (T) = 3 and 4. It is also isometric to quasi-isometric and has a diameter of 30-50 nm. LTR- retrotransposons are poorly characterized and lipids have not reported.

The genome integrates into the host genome and gets transcribed by host cell enzymes such as eukaryotic nuclear RNA polymerase II. Genome replication takes place in the host cytoplasm, or the nucleus and assembly can occur in the cytoplasm, or in the nucleus.

References

  1. ↑ Krupovic, M; Blomberg, J; Coffin, JM; Dasgupta, I; Fan, H; Geering, AD; Gifford, R; Harrach, B; Hull, R; Johnson, W; Kreuze, JF; Lindemann, D; Llorens, C; Lockhart, B; Mayer, J; Muller, E; Olszewski, N; Pappu, HR; Pooggin, M; Richert-Pöggeler, KR; Sabanadzovic, S; Sanfaçon, H; Schoelz, JE; Seal, S; Stavolone, L; Stoye, JP; Teycheney, PY; Tristem, M; Koonin, EV; Kuhn, JH (4 April 2018). "Ortervirales: A new viral order unifying five families of reverse-transcribing viruses". Journal of Virology. doi:10.1128/JVI.00515-18. PMID 29618642.
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