Nitric oxide synthase 2 (inducible)

NOS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4CX7, 4NOS
Identifiers
Aliases	NOS2, HEP-NOS, INOS, NOS, NOS2A, Nitric oxide synthase 2
External IDs	MGI: 97361 HomoloGene: 55473 GeneCards: NOS2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 27,756,766 bp[1] End 27,800,499 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 46.74 cM Start 78,920,787 bp[2] End 78,960,254 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • FMN binding • protein homodimerization activity • flavin adenine dinucleotide binding • arginine binding • tetrahydrobiopterin binding • metal ion binding • calmodulin binding • protein binding • heme binding • oxidoreductase activity • receptor binding • nitric-oxide synthase activity • NADPH-hemoprotein reductase activity • NADP binding Cellular component • cytoplasm • cytosol • cortical cytoskeleton • peroxisome • intracellular • perinuclear region of cytoplasm • cell nucleus • peroxisomal matrix • plasma membrane • vesicle membrane Biological process • positive regulation of guanylate cyclase activity • response to hypoxia • nitric oxide biosynthetic process • positive regulation of leukocyte mediated cytotoxicity • response to bacterium • negative regulation of protein catabolic process • regulation of insulin secretion • negative regulation of blood pressure • regulation of cytokine production involved in inflammatory response • positive regulation of killing of cells of other organism • negative regulation of gene expression • cell redox homeostasis • arginine catabolic process • prostaglandin secretion • interleukin-6 secretion • response to lipopolysaccharide • cellular response to drug • innate immune response in mucosa • regulation of cell proliferation • peptidyl-cysteine S-nitrosylation • defense response to bacterium • circadian rhythm • defense response to Gram-negative bacterium • nitric oxide mediated signal transduction • interleukin-8 secretion • cellular response to interferon-gamma • regulation of cellular respiration • cellular response to lipopolysaccharide • oxidation-reduction process • superoxide metabolic process • positive regulation of blood vessel diameter • cytokine-mediated signaling pathway • protein targeting to peroxisome • response to hormone Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4843	18126
Ensembl	ENSG00000007171	ENSMUSG00000020826
UniProt	P35228	P29477
RefSeq (mRNA)	NM_000625 NM_153292	NM_010927 NM_001313921 NM_001313922
RefSeq (protein)	NP_000616	NP_001300850 NP_001300851 NP_035057
Location (UCSC)	Chr 17: 27.76 – 27.8 Mb	Chr 11: 78.92 – 78.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.^[5]

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in the liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[6]

Interactions

Nitric oxide synthase 2A has been shown to interact with Caveolin 1^[7] and Rac2.^[8]

References