Niceritrol

Niceritrol
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	C10AD01 (WHO) ;
Identifiers
	IUPAC name 3-[(pyridin-3-yl)carbonyloxy]-2,2-bis({[(pyridin-3-yl)carbonyloxy]methyl})propyl pyridine-3-carboxylate;
PubChem CID	4476;
ChemSpider	4321 ;
UNII	F54EHJ34MV;
KEGG	D01754 ;
ECHA InfoCard	100.025.017
Chemical and physical data
Formula	C29H24N4O8
Molar mass	556.523 g/mol
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=CN=C1)C(=O)OCC(COC(=O)C2=CN=CC=C2)(COC(=O)C3=CN=CC=C3)COC(=O)C4=CN=CC=C4;
	InChI InChI=1S/C29H24N4O8/c34-25(21-5-1-9-30-13-21)38-17-29(18-39-26(35)22-6-2-10-31-14-22,19-40-27(36)23-7-3-11-32-15-23)20-41-28(37)24-8-4-12-33-16-24/h1-16H,17-20H2 ; Key:KUEUWHJGRZKESU-UHFFFAOYSA-N ;
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Niceritrol is a niacin derivative used as a hypolipidemic agent. It is an ester of pentaerythritol and nicotinic acid, has general properties similar to those of nicotinic acid (Nicotinamide), to which it is slowly hydrolysed. Niceritrol has been used as a lipid regulating drug in hyperlipidaemias and as a vasodilator in the treatment of peripheral vascular disease.^[1]^[2]

References

↑ Owada A.; Suda S; Hata T. (2003). "Antiproteinuric effect of niceritrol, a nicotinic acid derivative, in chronic renal disease with hyperlipidemia: a randomized trial". Am J Med. 114 (5): 347–53. doi:10.1016/s0002-9343(02)01567-x. PMID 12714122.
↑ Truven Health Analytics Inc. (May 8, 2008). "Niceritrol". Micromedexsolutions.com. Retrieved December 14, 2014.

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[Owada-1] Owada A.; Suda S; Hata T. (2003). "Antiproteinuric effect of niceritrol, a nicotinic acid derivative, in chronic renal disease with hyperlipidemia: a randomized trial". Am J Med. 114 (5): 347–53. doi:10.1016/s0002-9343(02)01567-x. PMID 12714122.

[Micro-2] Truven Health Analytics Inc. (May 8, 2008). "Niceritrol". Micromedexsolutions.com. Retrieved December 14, 2014.