M7GpppX diphosphatase

M7GpppX diphosphatase
Identifiers
EC number 3.6.1.59
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

M7GpppX diphosphatase (EC 3.6.1.59, DcpS, m7GpppX pyrophosphatase, m7GpppN m7GMP phosphohydrolase) is an enzyme with systematic name m7G5'ppp5'N m7GMP phosphohydrolase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(1) m7G5'ppp5'N(3'ppp5'N)n + H2O 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
(2) 7-methylguanosine 5'-diphosphate + H2O 7-methylguanosine 5'-phosphate + phosphate

Decapping is a process in the control of eukaryotic mRNA degradation.

References

  1. ↑ Malys, N.; McCarthy, J.E. (2006). "Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies". J. Mol. Biol. 363: 370–382. doi:10.1016/j.jmb.2006.08.015. PMID 16963086.
  2. ↑ Liu, S.W.; Rajagopal, V.; Patel, S.S.; Kiledjian, M. (2008). "Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme". J. Biol. Chem. 283 (24): 16427–16436. doi:10.1074/jbc.M800341200. PMC 2423256. PMID 18441014.
  3. ↑ Liu, H.; Rodgers, N.D.; Jiao, X.; Kiledjian, M. (2002). "The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases". EMBO J. 21: 4699–4708. doi:10.1093/emboj/cdf448. PMC 126188. PMID 12198172.
  4. ↑ van Dijk, E.; Le Hir, H.; Seraphin, B. (2003). "DcpS can act in the 5′-3′ mRNA decay pathway in addition to the 3′-5′ pathway". Proc. Natl. Acad. Sci. USA. 100: 12081–12086. doi:10.1073/pnas.1635192100. PMC 218716. PMID 14523240.
  5. ↑ Chen, N.; Walsh, M.A.; Liu, Y.; Parker, R.; Song, H. (2005). "Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping". J. Mol. Biol. 347: 707–718. doi:10.1016/j.jmb.2005.01.062. PMID 15769464.
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